Results 191 to 200 of about 451,629 (401)

Survey of Human Mitochondrial Diseases Using New Genomic/Proteomic Tools [PDF]

open access: yes, 2001
BACKGROUND. We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein mutations that give rise to human ...
Mohr, Scott C.   +2 more
core   +2 more sources

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

open access: yesAdvanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun   +11 more
wiley   +1 more source

The complete mitochondrial genome of a transitional form in secondary endosymbiotic Cryptophyte algae Guillardia theta strain CCMP2712

open access: yesMitochondrial DNA. Part B. Resources, 2018
The complete mitochondrial genome of Guillardia theta strain CCMP2712 was sequenced, assembled, and annotated in this study. The circular genome is 35,013 bp in size and it contains 36 protein-coding genes (PCGs), 28 transfer RNA genes (tRNA), and 2 ...
Feiya Suo   +3 more
doaj   +1 more source

Complete mitochondrial genome sequencing of Oxycarenus laetus (Hemiptera: Lygaeidae) from two geographically distinct regions of India [PDF]

open access: gold, 2021
Shruthi Chalil Sureshan   +5 more
openalex   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

open access: yesAdvanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode   +16 more
wiley   +1 more source

Analysis of complete mitochondrial genome of Matuta planipes (Decapoda, Brachyura, Matutidae) from South Korea

open access: yesMitochondrial DNA. Part B. Resources, 2019
In the present study, a complete mitochondrial genome of the moon crab species, Matuta planipes was sequenced and analyzed. This is the second complete mitochondrial genome record for the species and the first record from South Korea.
Jung-Il Kim   +3 more
doaj   +1 more source

Sharing of heteroplasmies between human liver lobes varies across the mtDNA genome

open access: yes, 2019
Mitochondrial DNA (mtDNA) heteroplasmy (intra-individual variation) varies among different human tissues and increases with age, suggesting that the majority of mtDNA heteroplasmies are acquired, rather than inherited.
Eis-Hübinger, A.   +6 more
core   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

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