Results 61 to 70 of about 294,629 (332)

Discovering functional DNA elements using population genomic information: A proof of concept using human mtDNA [PDF]

, 2014
Identifying the complete set of functional elements within the human genome would be a windfall for multiple areas of biological research including medicine, molecular biology, and evolution. Complete knowledge of function would aid in the prioritization of loci when searching for the genetic bases of disease or adaptive phenotypes.
arxiv   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Complete mitochondrial genome of the freshwater bryozoan Pectinatella magnifica (Phylactolaemata: Plumatellida) assembled from next-generation sequencing data

Mitochondrial DNA. Part B. Resources, 2018
The complete mitochondrial genome of the freshwater bryozoan Pectinatella magnifica was sequenced. The circular mitochondrial genome is 17,539 bp and consists of 13 protein-coding, two ribosomal RNA, and 22 transfer RNA genes (GenBank accession no ...
Jeong-Soo Gim, Eui-Jeong Ko, Hyo-Gyeum Kim, Young-Min Kim, Sungwon Hong, Hyun-Woo Kim, Jeong-An Gim, Gea-Jae Joo, Hyunbin Jo   +8 more
doaj   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

The first complete mitochondrial genome of eggplant (Solanum melongena)

Mitochondrial DNA. Part B. Resources, 2021
Eggplant is an important vegetable crop because of its rich nutrition, but to date no mitochondrial genome has been reported. In this study, the complete mitochondrial genome of the eggplant was sequenced. The complete mitochondrial genome was 498,136bp,
Dandan Li, Weiliu Li, Guiyun Gan, Wenjia Li, Yaqin Jiang, Xuyu Liang, Riyuan Chen, Yikui Wang   +7 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Complete mitochondrial genome of Favonigobius gymnauchen (BLEEKER, 1850) assembled from next-generation sequencing data

Mitochondrial DNA. Part B. Resources, 2019
The complete mitochondrial genome of Favonigobius gymnauchen was sequenced. The circular mitochondrial genome is 16,480 bp and consists of 13 protein-coding, 2 ribosomal RNAs, and 13 transfer RNA genes (GenBank accession no. MN194589). Results of maximum
Hyunbin Jo, Kiyun Park, Dong-Kyun Kim, Ihn-Sil Kwak   +3 more
doaj   +1 more source

The first complete mitochondrial genome of Macalpinomyces bursus (Ustilaginales: Ustilaginaceae) and insights into its phylogeny

Mitochondrial DNA. Part B. Resources, 2021
In the present study, the complete mitochondrial genome of Macalpinomyces bursus (Berk.) Vanky 2002 was sequenced and assembled. The complete mitochondrial genome of M. bursus was 49,024 bp in length, with the GC content of 30.4%. The M.
Peng Wang, Tianhao Lu, Jingwei Huang
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Complete mitochondrial genome of xanthid crab Atergatis floridus (Linnaeus, 1767)

Mitochondrial DNA. Part B. Resources, 2018
The complete mitochondrial genome sequenced from the floral egg crab Atergatis floridus (Linnaeus, 1767) and the determination of the position of the species in the reconstructed phylogenetic tree of the infraorder Brachyura using the protein coding ...
Mustafa Zafer Karagozlu, Michelle M. Barbon, Thinh Do Dinh, Cesar G. Demayo, Chang-Bae Kim   +4 more
doaj   +1 more source