Results 81 to 90 of about 270,006 (355)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The complete mitochondrial genome of Korean Marchantia polymorpha subsp. ruderalis Bischl. & Boisselier: inverted repeats on mitochondrial genome between Korean and Japanese isolates

Mitochondrial DNA Part B: Resources, 2019
Based on previous studies of Marchantia polymorpha subsp. ruderalis chloroplast genomes, few sequence variations were identified. Here, we sequenced complete mitochondrial genome of Korean isolate, named as KDBI00084, for uncovering sequence variations ...
Woochan Kwon, Yongsung Kim, Jongsun Park
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Complete mitochondrial genome of Favonigobius gymnauchen (BLEEKER, 1850) assembled from next-generation sequencing data

Mitochondrial DNA. Part B. Resources, 2019
The complete mitochondrial genome of Favonigobius gymnauchen was sequenced. The circular mitochondrial genome is 16,480 bp and consists of 13 protein-coding, 2 ribosomal RNAs, and 13 transfer RNA genes (GenBank accession no. MN194589). Results of maximum
Hyunbin Jo, Kiyun Park, Dong-Kyun Kim, Ihn-Sil Kwak   +3 more
doaj   +1 more source

The complete mitochondrial genome of tulip tree, Liriodendron tulipifera L. (Magnoliaceae): intra-species variations on mitochondrial genome

Mitochondrial DNA Part B: Resources, 2019
Liriodendron tulipifera L. is easily recognized by its heart-shaped of leaves and can grow up to 60 meters in North America. In this study, we presented second complete mitochondrial genome of L. tulipifera to understand intra-species variations.
Jongsun Park, Yongsung Kim, M. Kwon
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Complete mitochondrial genome of the freshwater bryozoan Pectinatella magnifica (Phylactolaemata: Plumatellida) assembled from next-generation sequencing data

Mitochondrial DNA. Part B. Resources, 2018
The complete mitochondrial genome of the freshwater bryozoan Pectinatella magnifica was sequenced. The circular mitochondrial genome is 17,539 bp and consists of 13 protein-coding, two ribosomal RNA, and 22 transfer RNA genes (GenBank accession no ...
Jeong-Soo Gim, Eui-Jeong Ko, Hyo-Gyeum Kim, Young-Min Kim, Sungwon Hong, Hyun-Woo Kim, Jeong-An Gim, Gea-Jae Joo, Hyunbin Jo   +8 more
doaj   +1 more source

The complete mitochondrial genome of the Great evening bat Ia io (Chiroptera: Vespertiilionidae) from karst area, Southwestern China

Mitochondrial DNA. Part B. Resources, 2022
In this study, the complete mitochondrial genome of Ia io from Guizhou Province, China. The genome was a circular mitochondrial genome of 16689 bp in length, containing 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNA), 2 ribosomal RNA genes ...
Peng-Fei Luo, Wei-Feng Wang, Xing-Liang Wang, Ya-Li Wang, Si-Wei Wang, Sha-Sha Yan, Qing-Qing He, Jiang Zhou   +7 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source