Results 191 to 200 of about 307,001 (266)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Implementation of Synoptic Reports in Enhancing Documentation Practices in Pediatric Surgical Oncology: A Systematic Review. [PDF]

Cancers (Basel)
Unal A, Harrison D, Loh AHP, Albirair M, Shalkow-Klincovstein J, Qureshi S, Abib SCV, Lakhoo K, Abdelhafeez AH.   +8 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Diagnostic Documentation and Tumour Marker Availability Across Clinical Pathways in Real-World Gastric Cancer. [PDF]

Diagnostics (Basel)
Vieru AM, Rădulescu VM, Mustață ML, Trașcă E, Cazacu SM, Popa P, Ciurea T.   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Improving Pediatric Follow-Up Documentation Through a Structured Follow-Up Card: A Closed-Loop Quality Improvement Project in Sudan. [PDF]

Cureus
Mohamed BMA, Ibrahim ESA, Siedahmed HNK, Dafalla HMA, Almsbah AAA, Salih AAM, Salman Abdalgani HJ, Murdas SA, Hayo SGD, Suliman Ali NS, Malik RKA, Elmatari SOS, Osman AMA, Fatih W, Mohammed AHEO, Kanan Ahmed AA, Hassan AM, Abdulazeez RA, Mohamed WBS, Albadawy IMAH.   +19 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Unveiling Hidden Variations in Lung Fissures: A Cadaveric Perspective on Surgical and Diagnostic Challenges. [PDF]

Cureus
Raja B, Kulkarni MM, Vaishnani H, Musale AA, Nath J.   +4 more
europepmc   +1 more source