Results 91 to 100 of about 3,487,614 (309)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Development and Characterization of CO2–Responsive Intelligent Polymer Sealant

ACS Omega, 2023
Huimei Wu, Yishan Lou, Xiaopeng Zhai, Zhonghui Li, Bin Liu   +4 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Study on the migration mechanism of heterogeneous cuttings in long-reach horizontal wells

Scientific Reports
This study focuses on the transportation of non-uniform cuttings in the drilling process of long-reach horizontal wells, conducting a comprehensive theoretical analysis and experimental investigation.
Chunhua Wang, Shibin Li, Yue Qi, Zhenhua Zhang, Dianfu Zheng, Hui Zhong, Changhao Wang   +6 more
doaj   +1 more source

The mechanisms for pattern completion and pattern separation in the hippocampus

Frontiers in Systems Neuroscience, 2013
The mechanisms for pattern completion and pattern separation are described in the context of a theory of hippocampal function in which the hippocampal CA3 system operates as a single attractor or autoassociation network to enable rapid, one-trial ...
Edmund eRolls
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

An equivalent circulating density prediction model for extended-reach horizontal wells considering drill strings sinusoidal buckling

Scientific Reports
Sinusoidal buckling of drill strings will be easily caused during drilling process of extended-reach horizontal wells due to the factors such as excessive well length and larger friction torque, which will cause measurement errors of well depth and ...
Zhao Huang, Yanfei Li, Kun Jiang, Junrui Ge, Yue Gu, Zhiqiang Hu   +5 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Determinants of ThaiMOOC Engagement: A Longitudinal Perspective on Adoption to Continuance

Informatics
Massive Open Online Courses (MOOCs) have become increasingly prevalent in higher education, with the COVID-19 pandemic further accelerating their integration, particularly in developing countries.
Kanitsorn Suriyapaiboonwattana, Kate Hone   +1 more
doaj   +1 more source