Results 161 to 170 of about 4,406,015 (337)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Performance management in complex adaptive systems: a conceptual framework for health systems. [PDF]

BMJ Glob Health, 2021
Newton-Lewis T, Munar W, Chanturidze T.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

When does group chat promote cooperation in shared resource governance?

Humanities & Social Sciences Communications
When people use shared resources, overextraction can occur. While deliberation tends to mitigate shared resource exploitation problems, the question remains: under what conditions does group chat improve cooperation in shared resource dilemmas?
Minwoo Ahn, Raksha Balakrishna, Michael Simeone, Marco A. Janssen   +3 more
doaj   +1 more source

The Green Mirage: The EU’s Complex Relationship with Palm Oil Biodiesel in the Context of Environmental Narratives and Global Trade Dynamics

Energies
In the early 2000s, biofuels like biodiesel and bioethanol were seen as renewable alternatives to petroleum, driven by rising crude oil prices and environmental concerns.
Keith Waters, Suleyman O. Altiparmak, Shade T. Shutters, Cameron Thies   +3 more
doaj   +1 more source

A novel perspective of Australian primary care dietetics: Insights from an exploratory study using complex adaptive systems theory. [PDF]

Nutr Diet, 2022
Kirkegaard A, Ball L, Mitchell L, Williams LT.   +3 more
europepmc   +1 more source

The ecology of wisdom [PDF]

This is the first of two papers concerning wisdom as an ecosystem appearing in sequential editions of Management & Marketing journal. The notion of wisdom as an ecosystem, or “the wisdom ecology,” builds on work by Hays (2007) who first identified wisdom
J. Martin HAYS
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Pathways and approaches for scaling-up of community-based management of acute malnutrition programs through the lens of complex adaptive systems in South Sudan. [PDF]

Arch Public Health, 2022
Renzaho AMN, Dachi G, Ategbo E, Chitekwe S, Doh D.   +4 more
europepmc   +1 more source

DynCNET: a negotiation and coordination protocol for dynamic task assignment. [PDF]

Task assignment in Multi-Agent Systems is a complex coordination problem, especially in systems that operate under dynamic and changing conditions. Adaptive task assignment is used to handle these dynamic and changing circumstances.
Boucké, Nelis, De Roover, Willem, Holvoet, Tom, Weyns, Danny   +3 more
core