Results 161 to 170 of about 14,492,801 (287)

Unveiling simplexity: A new paradigm for understanding complex adaptive systems and driving technological innovation. [PDF]

Innovation (Camb)
Tomassi A, Falegnami A, Romano E.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The need for general adaptive capacity-Discussing resilience with complex adaptive systems theory. [PDF]

Risk Anal
Scharte B.
europepmc   +1 more source

Sensemaking and learning during the Covid-19 pandemic: A complex adaptive systems perspective on policy decision-making. [PDF]

World Dev, 2020
Angeli F, Montefusco A.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Large-Scale Modeling of Economic Systems

, 2013
Following the events of the credit crunch and the onset of a global reces- sion, alternative ways of modeling modern economies and mechanisms for carrying out policy analysis are now an urgent priority. Traditional mathematical economics is widely viewed
Worth, David, Van der Hoog, Sander, Coakley, Simon, Greenough, Chris, Raberto, Marco, Dawid, Herbert, Neugart, Michael, Cincotti, Silvano, Kiran, Mariam, Chin, Shawn, Gemkow, Simon, Harting, Philipp, Teglio, Andrea, Deissenberg, Christophe, Holcombe, Mike   +14 more
core  

Applying a complex adaptive systems approach to the evaluation of a school-based intervention for intimate partner violence prevention in Mexico. [PDF]

Health Policy Plan, 2020
Makleff S, Billowitz M, Garduño J, Cruz M, Silva Márquez VI, Marston C.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

On an irreducible theory of complex systems

, 2006
In the paper we present results to develop an irreducible theory of complex systems in terms of self-organization processes of prime integer relations. Based on the integers and controlled by arithmetic only the self-organization processes can describe ...
Victor Korotkikh (9811187), Korotkikh, Galina Alexandra., Korotkikh, Victor., Galina Korotkikh (9811184)   +3 more
core  

Defining conceptual artefacts to manage and design simplicities in complex adaptive systems. [PDF]

Heliyon
Falegnami A, Tomassi A, Gunella C, Amalfitano S, Corbelli G, Armonaite K, Fornaro C, Giorgi L, Pollini A, Caforio A, Romano E.   +10 more
europepmc   +1 more source