Results 151 to 160 of about 14,492,801 (287)

Examining innovation in hospital units: a complex adaptive systems approach. [PDF]

BMC Health Serv Res, 2020
Glover WJ, Nissinboim N, Naveh E.
europepmc   +1 more source

A Transdisciplinary Complex Adaptive Systems (T-CAS) Approach to Developing a National School-Based Culture of Prevention for Health Improvement: the School Health Research Network (SHRN) in Wales. [PDF]

Prev Sci, 2021
Murphy S, Littlecott H, Hewitt G, MacDonald S, Roberts J, Bishop J, Roberts C, Thurston R, Bishop A, Moore L, Moore G.   +10 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

From Simplistic to Complex Systems in Economics [PDF]

The applicability of complex systems theory in economics is evaluated and compared with standard approaches to economic theorizing based upon constrained optimization.
Prof John Foster
core  

AI-driven automation of aviation equipment inspection: Insights from a complex adaptive systems perspective. [PDF]

Innovation (Camb)
Wu P, Wen W, Li H, Li Z, Zeng N.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A complex adaptive systems model of labour reciprocity and normative reasoning in swidden agriculture. [PDF]

R Soc Open Sci
Tverskoi D, Scaggs SA, Downey SS.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Systems Thinking in Mental Health Patient Safety: A Narrative Review of Complex Adaptive Systems. [PDF]

J Eval Clin Pract
Challinor A, Bifarin O, Khedmati Morasae E, Saini P, Berzins K, Nathan R.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source