Results 151 to 160 of about 4,406,015 (337)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Markov network approach for reproducing purchase behaviours observed in convenience stores

Scientific Reports
The convenience store industry in Japan holds immense significance, making a thorough comprehension of customer purchase behaviour invaluable for companies aiming to gain insights into their customer base. In this paper, we propose a novel application of
Dan Johansson, Hideki Takayasu, Misako Takayasu   +2 more
doaj   +1 more source

Mapping communities as complex adaptive systems: A study of the response to violence against women by communities in Samoa. [PDF]

PLoS One, 2023
Lowe H, Apelu L, Brown L, Tanielu H, Mannell J.   +4 more
europepmc   +1 more source

Optimisation in ‘Self-modelling’ Complex Adaptive Systems

, 2011
When a dynamical system with multiple point attractors is released from an arbitrary initial condition it will relax into a configuration that locally resolves the constraints or opposing forces between interdependent state variables. However, when there
Buckley, C. L., Mills, Rob, Watson, Richard A.   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Transitioning to a green economy: Radical labor transformation or building upon existing skills?

Sustainability Analytics and Modeling
Transitioning to a “green” economy will require many industries to change their activities, raising concerns about the elimination of occupations and the need for significant retraining of the workforce.
Shade T. Shutters, José Lobo
doaj   +1 more source

Applying the Free Energy Principle to Complex Adaptive Systems. [PDF]

Entropy (Basel), 2022
Badcock PB, Ramstead MJD, Sheikhbahaee Z, Constant A.   +3 more
europepmc   +1 more source

The Use of Complex Adaptive Systems as a Generative Metaphor in an Action Research Study of an Organisation [PDF]

, 2008
Understanding the dynamic behaviour of organisations is challenging and this study uses a model of complex adaptive systems as a generative metaphor to address this challenge.
Brown, Callum
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Caution as a Response to Scientific Uncertainty: A Groundwater Game Experiment

International Journal of the Commons
Understanding and managing uncertainty is critical for robust governance. In groundwater management, where collaborative, community-based governance is increasingly common, scientific uncertainty about hydrological conditions could pose challenges to ...
Minwoo Ahn, Elizabeth Baldwin, Dylan Girone   +2 more
doaj   +1 more source