Results 81 to 90 of about 4,406,015 (337)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

DTCNS: A python toolbox for digital twin-oriented complex networked systems

open access: yesSoftwareX
Digital Twin-Oriented Complex Networked System (DT-CNS) is a modelling paradigm aiming at the representation and analysis of real-world networked systems.
Jiaqi Wen   +2 more
doaj   +1 more source

Robustness of higher-order networks with synergistic protection

open access: yesNew Journal of Physics, 2023
From chemical reactions to human communications, higher-order interactions are ubiquitous in real-world networks. Entities within higher-order interactions often exhibit collective behaviors that could create synergistic effects on robustness of the ...
Qihang Chen   +3 more
doaj   +1 more source

Complex Adaptive Systems [PDF]

open access: yes, 1994
The various groups at the Santa Fe Institute studying complex adaptive systems (CAS) have somewhat different points of view and have adopted different vocabularies. Some of us speak of "artificial life" or "artificial social life" or "artificial worlds,"
Gell-Mann, Murray
core  

Transforming a linear module into an adaptive one : tackling the challenge [PDF]

open access: yes, 2010
Every learner is fundamentally different. However, few courses are delivered in a way that is tailored to the specific needs of each student. Delivery systems for adaptive educational hypermedia have been extensively researched and found promising. Still,
Cristea, Alexandra I.   +1 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Contribution of systems thinking and complex adaptive system attributes to sustainable food production: Example from a climate-smart village

open access: yesAgricultural Systems, 2019
Climate-smart agriculture (CSA) conceptually has the potential to contribute to the sustainable development goals of achieving zero hunger, reducing land degradation, eliminating poverty, tackling climate change, and promoting gender equality.
Renata Jagustović   +5 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Theory of deferred action: Agent-based simulation model for designing complex adaptive systems [PDF]

open access: yes, 2009
Deferred action is the axiom that agents act in emergent organisation to achieve predetermined goals. Enabling deferred action in designed artificial complex adaptive systems like business organisations and IS is problematical.
Eldabi, T, Khan, T, Patel, NV
core  

Home - About - Disclaimer - Privacy