Results 101 to 110 of about 4,406,015 (337)

Complexity Theory, Adaptation, and Administrative Law [PDF]

, 2005
Recently, commentators have applied insights from complexity theory to legal analysis generally and to administrative law in particular. This Article focuses on one of the central problems that complexity.
Hornstein, Donald T.
core   +2 more sources

A complex adaptive systems approach to the kinetic folding of RNA

, 2005
The kinetic folding of RNA sequences into secondary structures is modeled as a complex adaptive system, the components of which are possible RNA structural rearrangements (SRs) and their associated bases and base pairs. RNA bases and base pairs engage in
Abrahams, Baker, Cannone, Fisher, Flamm, Fontana, Freier, Gratias, Gultyaev, Hadany, Higgs, Hofacker, Isambert, Kauffman, Kauffman, Kawasaki, Lee, Levin, Mathews, Mathews, McCarthy, Metropolis, Mironov, Mochizuki, Morgan, Nagel, Ndifon, Poerschke, Poerschke, Schuster, Schuster, Schuster, Skellett, Tang, Vitreschack, Wilfred Ndifon, Woese, Wolfinger, Xayaphoummine, Yang, Zamora, Zhang   +41 more
core   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Hyperbox Mixture Regression for process performance prediction in antibody production

Digital Chemical Engineering
This paper addresses the challenges of predicting bioprocess performance, particularly in monoclonal antibody (mAb) production, where conventional statistical methods often fall short due to time-series data’s complexity and high dimensionality.
Ali Nik-Khorasani, Thanh Tung Khuat, Bogdan Gabrys   +2 more
doaj   +1 more source

Time-Dependent Random Walks and the Theory of Complex Adaptive Systems

, 2002
Motivated by novel results in the theory of complex adaptive systems, we analyze the dynamics of random walks in which the jumping probabilities are {\it time-dependent}. We determine the survival probability in the presence of an absorbing boundary. For
B. D. Hughes, E. Sparre Andersen, E. Sparre Andersen, J. Marro, Shahar Hod, T. M. Liggett   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Complex systems vs. complex adaptive systems: why the difference matters

Frontiers in Complex Systems
Terms such as “complexity,” “complex systems,” and “complex adaptive systems” have moved rapidly from specialist research into the vocabularies of policy, sustainability practice, business, and health.
Shade T. Shutters, Shade T. Shutters, Kelle Dhein   +2 more
doaj   +1 more source

A spiral model for adding automatic, adaptive authoring to adaptive hypermedia [PDF]

, 2008
At present a large amount of research exists into the design and implementation of adaptive systems. However, not many target the complex task of authoring in such systems, or their evaluation.
Cristea, Alexandra I., Hendrix, Maurice
core   +3 more sources

Teams as Complex Adaptive Systems: Reviewing 17 Years of Research

Small Group Research, 2017
At the turn of the century, Arrow, McGrath, and Berdahl portrayed teams as complex adaptive systems (CAS). And yet, despite broad agreement that this approach facilitates a better understanding of teams, it has only now been timidly incorporated into ...
Pedro J. Ramos-Villagrasa, Pedro Marques-Quinteiro, J. Navarro, Ramón Rico   +3 more
semanticscholar   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source