Results 111 to 120 of about 4,406,015 (337)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
GamesBetween 1959 and 1962, Alvin Scodel, J. Sayer Minas, and colleagues conducted some of the earliest laboratory studies of strategic interaction using non-zero-sum games.
Shade T. Shutters
doaj +1 more source
Prospects for large-scale financial systems simulation
, 2011 As the 21st century unfolds, we find ourselves having to control, support, manage or otherwise cope with large-scale complex adaptive systems to an extent that is unprecedented in human history.
Bullock, Seth
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2020 Complex adaptive systems (CAS) consist of diverse components that are interdependent, act as a unified whole, and have the ability to learn from experience and to adapt to change in the environment. Examples of CAS are the global economy, stock markets, emerging cities, online social networks, and the internet.
Sammut-Bonnici, Tanya +2 more
openaire +1 more source
Regional Innovation Systems as Complex Adaptive Systems: The Case of Lagging European Regions
Sustainability, 2018 This article proposes an agent-based model to support the development of self-sustaining regional innovation systems (RIS). The model is the base of a computational laboratory, CARIS (Complex Adaptive Regional Innovation System), which aims at evaluating
C. Ponsiglione, I. Quinto, G. Zollo
semanticscholar +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Implications of external validity for research on polycentric and complex adaptive systems [PDF]
Much recent research has examined the implications of policy analysis for complex adaptive social-ecological systems. System complexity comes from both the natural environment as well as complex institutional arrangements that humans use to manage and ...
Coleman, Eric A.
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Governance of a complex system: water [PDF]
, 2014 This paper sets out a complex adaptive systems view of water governance. Overview Fresh water is a life - enabling resource as well as the source of spiritual, social and economic wellbeing and development.
Elizabeth Eppel
core +1 more source