In the context of applying artificial intelligence to the legal domain, building legal question-answering (QA) systems requires a structured, queryable, and inferable knowledge foundation.
Huynh Le Huy +2 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Mapping communities as complex adaptive systems: A study of the response to violence against women by communities in Samoa. [PDF]
Lowe H +4 more
europepmc +1 more source
The ubiquitin system in normal and infected germinal center B cells
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Using complex adaptive systems to investigate Aboriginal-tourism relationships in Purnululu National Park: exploring the role of capital [PDF]
Resource management systems such as national parks are complex and dynamic with strong interdependencies between their human and ecological components. Their management has become more difficult as scale, impacts and consequences have increased and local
Allison, H.E. +2 more
core
Detection of ChatGPT fake science with the xFakeSci learning algorithm
Generative AI tools exemplified by ChatGPT are becoming a new reality. This study is motivated by the premise that “AI generated content may exhibit a distinctive behavior that can be separated from scientific articles”.
Ahmed Abdeen Hamed, Xindong Wu
doaj +1 more source
Applying the Free Energy Principle to Complex Adaptive Systems. [PDF]
Badcock PB +3 more
europepmc +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Prospects for large-scale financial systems simulation
As the 21st century unfolds, we find ourselves having to control, support, manage or otherwise cope with large-scale complex adaptive systems to an extent that is unprecedented in human history.
Bullock, Seth
core +1 more source
A Markov network approach for reproducing purchase behaviours observed in convenience stores
The convenience store industry in Japan holds immense significance, making a thorough comprehension of customer purchase behaviour invaluable for companies aiming to gain insights into their customer base. In this paper, we propose a novel application of
Dan Johansson +2 more
doaj +1 more source

