Results 91 to 100 of about 14,492,801 (287)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Transfer learning and the early estimation of single-photon source quality using machine learning methods

Machine Learning: Science and Technology
The use of single-photon sources (SPSs) is central to numerous systems and devices proposed amidst a modern surge in quantum technology. However, manufacturing schemes remain imperfect, and single-photon emission purity must often be experimentally ...
David Jacob Kedziora, Anna Musiał, Wojciech Rudno-Rudziński, Bogdan Gabrys   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Implications of external validity for research on polycentric and complex adaptive systems [PDF]

Much recent research has examined the implications of policy analysis for complex adaptive social-ecological systems. System complexity comes from both the natural environment as well as complex institutional arrangements that humans use to manage and ...
Coleman, Eric A.
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

ACM Transactions on Autonomous and Adaptive Systems

, 2020
Aims and Scope ACM Transactions on Autonomous and Adaptive Systems (TAAS) is a venue for high quality research contributions addressing foundational, engineering, and technological aspects related to all those complex ICT systems that have to serve - in
OMICINI, ANDREA
core   +1 more source

Public Recognition of the Need for Science–Practice Knowledge Co-Production in Complex Systems: Evidence from the D-A-CH Region

Systems
Background: Science–practice knowledge co-production, grounded in mutual learning, is a key strategy for generating and integrating knowledge to support informed decision-making in the face of complex societal challenges.
Gerald Steiner, Martin Bertau, Filippina Risopoulos-Pichler, Shade T. Shutters, Susanne Strohmaier, Peter Harold, Dina Ziganshina Lienhard, Markkus Pfirman Schlosser, Manfred D. Laubichler, Eva S. Schernhammer   +9 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Symmetric complex-valued RBF receiver for multiple-antenna aided wireless systems

, 2008
A nonlinear beamforming assisted detector is proposed for multiple-antenna-aided wireless systems employing complex-valued quadrature phase shift-keying modulation.
Tan, S., Chen, Sheng, Hanzo, L.
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source