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Complex chromosomal rearrangements.
Genetic counseling (Geneva, Switzerland), 2007Complex Chromosomal Rearrangements (CCRs) are constitutional structural rearrangements involving three or more chromosomes or having more than two breakpoints. CCRs preferentially occur during spermatogenesis and are transmitted in families through oogenesis.
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FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangements
Cytogenetic and Genome Research, 2000We combined the techniques of fluorescence in situ hybridization (FISH) and chromosomal microdissection in one experiment (FISH-MD). This novel method permits rapid identification of the composition, origin, and breakpoints of rearranged chromosomes. Rearranged chromosomes are first identified by multicolor-FISH, then the fluorophore-labeled derivative
J, Weimer, M, Kiechle, N, Arnold
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Complex chromosomal rearrangement in a woman with multiple miscarriages
American Journal of Medical Genetics, 1988AbstractWe report on a 23‐yr‐old healthy female with repeated miscarriages and a de novo complex chromosomal rearrangement (CCR) involving chromosomes 1, 2, 5 and 11 with 5 breakpoints. A review of cases reported in the last five yr is provided.
Katrin Kausch +5 more
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A balanced complex chromosomal rearrangement (BCCR) with phenotypic effect
Clinical Genetics, 1991The authors report on a case of balanced complex chromosomal rearrangement (BCCR) with phenotypic effect, describe the dysmorphisms and malformations observed, and discuss the various pathogenetic mechanisms. On the basis of these considerations, they underline the need for careful reporting of examined cases, distinguishing the characteristic signs ...
G, Del Porto +5 more
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Complex familial rearrangement of chromosome 9p24.3 detected by FISH
American Journal of Medical Genetics, 1998We describe a newborn male with minor facial anomalies, pyloric stenosis, and a chromosome rearrangement that involves deletion and addition of material at 9p24.3. Routine studies showed a 46, XY, add (9) (p24) karyotype. Fluorescence in situ hybridization (FISH) with two different whole chromosome probes for chromosome 9 failed to identify whether the
G M, Repetto +3 more
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A complex rearrangement of chromosome 7 in human astrocytoma
Cancer Genetics and Cytogenetics, 2004Chromosome 7 is a frequent site of cytogenetic aberrations in human astrocytomas. One region that is often targeted in human astrocytomas is on 7p. The U251 human glioblastoma cell line has a region of gain of genetic material on 7p similar to that seen in human astrocytomas.
Anjan, Misra +3 more
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Complex chromosome rearrangements involving 12q14 in two uterine leiomyomas
Cancer Genetics and Cytogenetics, 1990Cytogenetic analysis of short-term cultures from 10 uterine leiomyomas revealed normal karyotypes in 8 and clonal complex chromosome rearrangements in 2 tumors. In both leiomyomas with clonal abnormalities, 12q14, but not 14q22-24, was involved in translocations with 1q43 in one tumor and with 12q24 in the other.
N, Pandis +5 more
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Balanced complex chromosome rearrangements: Reproductive aspects. A review
American Journal of Medical Genetics Part A, 2012AbstractThis review examines the reproductive consequences for carriers of a balanced complex chromosome rearrangement (CCR). It is based on an analysis of CCRs in 103 adults referred for reproductive problems, including male infertility. The main focus is on reproductive risks based on data from 84 CCRs.
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Complex Chromosomal Rearrangements
Clinical Genetics, 1981Michael R. Creasy, John A. Crolla
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