Results 161 to 170 of about 93,691 (297)

Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status

International Journal of Cancer, EarlyView.
What's New? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Klaus W. Fagerstedt, Sami Kilpinen, Johanna Arola, Benjamin Z. Sundqvist, Tom Böhling, Leif C. Andersson, Harri Sihto   +6 more
wiley   +1 more source

ECCFP: A consecutive full pass‐based bioinformatic analysis for eccDNA identification from long‐read sequencing data

iMetaOmics, EarlyView.
A new bioinformatics pipeline called ECCFP has been developed to improve the detection of extrachromosomal circular DNA (eccDNA) from long‐read sequencing data. ECCFP uses all consecutive full passes from individual reads for candidate eccDNA identification and consolidates candidate eccDNAs to generate accurate unique eccDNA.
Wang Li, Biyuan Miao, Jun Zhang, Qingsong Zeng, Tangxuan Zhang, Zetong Wu, Yusheng Song, Mengting Li, Lilu Guo, Juan Luo, Jingxiang Xu, Tianliang Liu, Shifu Chen, Jia Gu, Shaogui Wan   +14 more
wiley   +1 more source

Fast bootstrap and reliable readout using hidden references for DNA data storage

iMeta, EarlyView.
This study provides a bootstrap readout framework for DNA data storage based on multiple‐fold hidden references. We employ a multi‐stage alignment and error correction strategy, transforming the de novo readout into a resequencing‐like workflow. Correlation to the hidden watermark reference identifies low‐error‐rate reads, and bit‐wise consensus ...
Weigang Chen, Shuang Liu, Quan Guo, Rui Qin, Qi Ge, Tingting Qi, Yingjin Yuan   +6 more
wiley   +1 more source

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

CCRR: a user-friendly platform for analyzing complex chromosomal rearrangements in tumors. [PDF]

Bioinformatics
Liu J, Wang K, Yuan Y, Bao G, Ci H, Liu M, Lyu Y, Tang J, Yang J, Cai H.   +9 more
europepmc   +1 more source

Stable transmission of complex chromosomal rearrangements involving chromosome 1q derived from constitutional chromoanagenesis. [PDF]

Mol Cytogenet, 2019
Gudipati MA, Waters E, Greene C, Goel N, Hoppman NL, Pitel BA, Webley MR, Zou Y.   +7 more
europepmc   +1 more source

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Complex chromosomal rearrangements in female carriers experiencing recurrent pregnancy loss or poor obstetric history and literature review. [PDF]

J Assist Reprod Genet
Sheth F, Shah J, Liehr T, Desai M, Patel H, Sheth J, Sheth H.   +6 more
europepmc   +1 more source