The molecular basis of T cell acute lymphoblastic leukemia [PDF]
, 2012 T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando +23 more
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A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers. [PDF]
, 2016 Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known.
Bell, Sara N +10 more
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Array-CGH and multipoint FISH to decode complex chromosomal rearrangements
BMC Genomics, 2006 Background Recently, several high-resolution methods of chromosome analysis have been developed. It is important to compare these methods and to select reliable combinations of techniques to analyze complex chromosomal rearrangements in tumours.
Dumanski Jan +7 more
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Chromosomal diversification and karyotype evolution of diploids in the cytologically diverse genus Prospero (Hyacinthaceae) [PDF]
, 2013 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Andrew R Leitch +7 more
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Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis [PDF]
, 2013 Chromosomal rearrangements can radically alter gene products and their function, driving tumor formation or progression. However, the molecular origins and evolution of such rearrangements are varied and poorly understood, with cancer cells often ...
Cheeseman, Iain M, Gascoigne, Karen E.
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Biotechnology & Biotechnological Equipment, 2019 Preimplantation genetic testing (PGT) is presently the only option available for detecting genetic conditions in embryos created through in vitro fertilization (IVF) prior to implantation.
Slavyana Yaneva Staykova +7 more
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Catastrophic chromosomal restructuring during genome elimination in plants. [PDF]
, 2015 Genome instability is associated with mitotic errors and cancer. This phenomenon can lead to deleterious rearrangements, but also genetic novelty, and many questions regarding its genesis, fate and evolutionary role remain unanswered.
Bradnam, Keith R +9 more
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The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA [PDF]
, 2018 Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation.
Barra V., Fachinetti D.
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Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]
, 2000 At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Braun, S. +5 more
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BMC Plant Biology, 2022 Background Karyotype dynamics driven by chromosomal rearrangements has long been considered as a fundamental question in the evolutionary genetics.
Zhuang Meng +5 more
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