Results 111 to 120 of about 2,087,732 (267)
The Complex Functions of the NME Family-A Matter of Location and Molecular Activity. [PDF]
Int J Mol Sci, 2021 Schlattner U.
europepmc +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Fractional Calculus and Hypergeometric Functions in Complex Analysis
Fractal and FractionalFractional calculus has had a powerful impact on recent research, with many applications in different branches of science and engineering [...]
Gheorghe Oros, Georgia Irina Oros
doaj +1 more source
How the Replication and Transcription Complex Functions in Jumping Transcription of SARS-CoV-2. [PDF]
Front Genet, 2022 Liang J +9 more
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Complex functions of Gcn5 and Pcaf in development and disease. [PDF]
Biochim Biophys Acta Gene Regul Mech, 2021 Koutelou E, Farria AT, Dent SYR.
europepmc +1 more source
Bounding the complexity of advice functions
[1992] Proceedings of the Seventh Annual Structure in Complexity Theory Conference, 1995 It was known that every set A in P/poly has an advice function in PF(¿P2(A)). This note shows that A also has an advice function in PF (NP(A) ¿¿p3). From this new bound, it is shown that separating ¿P2 and ¿p2 relative to a set in P/poly is as hard as obtaining the same separation, unrelativized.
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source