Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Phylogenetic and developmental analyses indicate complex functions of calcium-activated potassium channels in zebrafish embryonic development. [PDF]
Dev Dyn, 2021 Silic MR, Black MM, Zhang G.
europepmc +1 more source
Bandgap and Complex Dielectric Function from the Low-Loss Energy Spectrum for SnO2 Prismatic Nano-Rods. [PDF]
, 2021 Javier Eliel Morales-Mendoza +3 more
openalex +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Protein kinase PIM2: A simple PIM family kinase with complex functions in cancer metabolism and therapeutics. [PDF]
J Cancer, 2021 Wang Y, Xiu J, Ren C, Yu Z.
europepmc +1 more source
Ctp1 Is a Cell-Cycle-Regulated Protein that Functions with Mre11 Complex to Control Double-Strand Break Repair by Homologous Recombination [PDF]
, 2007 Oliver Limbo +5 more
openalex +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Volume Dimension of Mass Functions in Complex Networks
MathematicsA novel definition of volume dimension for a mass function based on a sigmoid asymptote is proposed; in particular, we extend the volume dimension of a mass function to define the volume dimensions for nodes and edges in complex networks.
Maria del Carmen Soto-Camacho +3 more
doaj +1 more source
The CRK2-CYC13 complex functions as an S-phase cyclin-dependent kinase to promote DNA replication in Trypanosoma brucei. [PDF]
BMC Biol, 2021 Lee KJ, Li Z.
europepmc +1 more source