Results 71 to 80 of about 18,185,297 (341)

Complexity of regular functions

open access: yesJournal of Computer and System Sciences, 2015
We give complexity bounds for various classes of functions computed by cost register automata.
Mertz, Ian, Allender, Eric
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Executive functions in the context of complex learning: Malleable moderators?

open access: yesFrontline Learning Research, 2017
Executive functions are crucial for complex learning in addition to prior knowledge. In this article, we argue that executive functions can moderate the effectiveness of instructional approaches that vary with respect to the demand on these functions. In
Matthias Schwaighofer   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Semi-analytic parameter identification for complex yield functions

open access: yesMATEC Web of Conferences, 2016
This paper presents a new parameter identification scheme for complex yield criteria of sheet metals using experimentally determined load and strain distributions and combining analytical stress analysis on sectional strain data with common inverse ...
Küsters Niklas, Brosius Alexander
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Modularized Functions of the Fanconi Anemia Core Complex

open access: yesCell Reports, 2014
The Fanconi anemia (FA) core complex provides the essential E3 ligase function for spatially defined FANCD2 ubiquitination and FA pathway activation. Of the seven FA gene products forming the core complex, FANCL possesses a RING domain with demonstrated ...
Yaling Huang   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

p-Trigonometric and p-Hyperbolic Functions in Complex Domain

open access: yesAbstract and Applied Analysis, 2016
We study extension of p-trigonometric functions sinp and cosp and of p-hyperbolic functions sinhp and coshp to complex domain. Our aim is to answer the question under what conditions on p these functions satisfy well-known relations for usual ...
Petr Girg, Lukáš Kotrla
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

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