CircAMOTL1 RNA and AMOTL1 Protein: Complex Functions of AMOTL1 Gene Products. [PDF]
Int J Mol Sci, 2023 Sadlak J +3 more
europepmc +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. [PDF]
Nat Struct Mol Biol, 2023 Bujarrabal-Dueso A +6 more
europepmc +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Fractional Calculus and Hypergeometric Functions in Complex Analysis
Fractal and FractionalFractional calculus has had a powerful impact on recent research, with many applications in different branches of science and engineering [...]
Gheorghe Oros, Georgia Irina Oros
doaj +1 more source
The Complex Functions of the NME Family-A Matter of Location and Molecular Activity. [PDF]
Int J Mol Sci, 2021 Schlattner U.
europepmc +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
How the Replication and Transcription Complex Functions in Jumping Transcription of SARS-CoV-2. [PDF]
Front Genet, 2022 Liang J +9 more
europepmc +1 more source
Computational complexity of functions
Theoretical Computer Science, 1996 Partial translation from [Levin 74]; preliminary version is in [Levin 73]
openaire +3 more sources