Results 141 to 150 of about 2,246,345 (266)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Major histocompatibility complex II serves as a prognostic biomarker in resectable pulmonary sarcomatoid carcinoma: development of a prediction model. [PDF]

Transl Lung Cancer Res
Wang H, Ye L, Liu X, Li Y, Chen Z, Zhang W, Liu Y, Chen X, Zhao W, Zhang Q, Huang R, Zeng J, Chen S, Li Y, Zhao L, Xu K, He Y.   +16 more
europepmc   +1 more source

Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors. [PDF]

JTO Clin Res Rep, 2023
Ikeda H, Nagasaki J, Shimizu D, Katsuya Y, Horinouchi H, Hosomi Y, Tanji E, Iwata T, Itami M, Kawazu M, Ohe Y, Suzuki T, Togashi Y.   +12 more
europepmc   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Mitochondrial complex II orchestrates divergent effects in CD4+ and CD8+ T cells. [PDF]

J Clin Invest
Seike K, Chu SA, Sumii Y, Ikeda T, Wu MC, Maneix L, Zhao D, Sun Y, Cieslik M, Reddy P.   +9 more
europepmc   +1 more source

Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation. [PDF]

Sci Adv, 2023
Reynolds MB, Hong HS, Michmerhuizen BC, Lawrence AE, Zhang L, Knight JS, Lyssiotis CA, Abuaita BH, O'Riordan MX.   +8 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Complex II assembly drives metabolic adaptation to OXPHOS dysfunction. [PDF]

Sci Adv
Kugapreethan R, Elahee Doomun SN, Sacharz J, Frazier AE, Sharma T, Low YC, Nie S, Leeming MG, Muellner-Wong L, Last K, Stait T, De Souza DP, Thorburn DR, McConville MJ, Stroud DA.   +14 more
europepmc   +1 more source

Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer. [PDF]

Cell Chem Biol, 2023
Ahanin EF, Sager RA, Backe SJ, Dunn DM, Dushukyan N, Blanden AR, Mate NA, Suzuki T, Anderson T, Roy M, Oberoi J, Prodromou C, Nsouli I, Daneshvar M, Bratslavsky G, Woodford MR, Bourboulia D, Chisholm JD, Mollapour M.   +18 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source