Results 71 to 80 of about 11,062,117 (306)
Frontiers in Pediatrics, 2020 Lamin A/C (LMNA) encodes for two nuclear intermediate filament proteins. Mutations in LMNA cause a highly heterogeneous group of diseases predominantly leading to muscular or cardiac disease, lipodystrophy syndromes, peripheral neuropathy, and ...
Anwar Baban +10 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Application of the complex network method in solid-state sintering
, 2013 The microstructure evolution and force distribution during solid-state sintering are studied at the particle length scale for a planar layer system of copper particles.
Chen SH(陈少华), Wang C(王超)
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Intelligent Anti-Jamming Decision-Making Technology Based on Knowledge Graph and DQN
SensorsRecent advancements in artificial intelligence have driven significant progress in intelligent anti-jamming communications. However, existing methods still face two major limitations: reinforcement learning-based models often suffer from slow convergence,
Dadong Ni +6 more
doaj +1 more source
International Journal of Modern Physics C, 2005 The Sznajd cellular automata corresponds to one of the simplest and yet most interesting models of complex systems. While the traditional two-dimensional Sznajd model tends to a consensus state (pro or cons), the assignment of the contrary to the dominant opinion to some of its cells during the system evolution is known to provide stabilizing feedback ...
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Predicting synthetic rescues in metabolic networks
Molecular Systems Biology, 2008 An important goal of medical research is to develop methods to recover the loss of cellular function due to mutations and other defects. Many approaches based on gene therapy aim to repair the defective gene or to insert genes with compensatory function.
Adilson E Motter +3 more
doaj +1 more source
Navigability of complex networks
Nature Physics, 2008 Routing information through networks is a universal phenomenon in both natural and manmade complex systems. When each node has full knowledge of the global network connectivity, finding short communication paths is merely a matter of distributed computation.
Marián Boguñá +2 more
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source