Results 71 to 80 of about 10,677,913 (302)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Intelligent Anti-Jamming Decision-Making Technology Based on Knowledge Graph and DQN
SensorsRecent advancements in artificial intelligence have driven significant progress in intelligent anti-jamming communications. However, existing methods still face two major limitations: reinforcement learning-based models often suffer from slow convergence,
Dadong Ni +6 more
doaj +1 more source
International Journal of Modern Physics C, 2005 The Sznajd cellular automata corresponds to one of the simplest and yet most interesting models of complex systems. While the traditional two-dimensional Sznajd model tends to a consensus state (pro or cons), the assignment of the contrary to the dominant opinion to some of its cells during the system evolution is known to provide stabilizing feedback ...
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Predicting synthetic rescues in metabolic networks
Molecular Systems Biology, 2008 An important goal of medical research is to develop methods to recover the loss of cellular function due to mutations and other defects. Many approaches based on gene therapy aim to repair the defective gene or to insert genes with compensatory function.
Adilson E Motter +3 more
doaj +1 more source
Navigability of complex networks
Nature Physics, 2008 Routing information through networks is a universal phenomenon in both natural and manmade complex systems. When each node has full knowledge of the global network connectivity, finding short communication paths is merely a matter of distributed computation.
Marián Boguñá +2 more
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2011 Abstracting the general concept of information andrelative state of element, based on the structure and state researchof complex network, this paper takes the branch potential energy asedge weight into the complex network modeling process of powersystem.
Jun Li +3 more
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