Results 81 to 90 of about 11,062,117 (306)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2011 Abstracting the general concept of information andrelative state of element, based on the structure and state researchof complex network, this paper takes the branch potential energy asedge weight into the complex network modeling process of powersystem.
Jun Li +3 more
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Impact of removing nodes on the controllability of complex networks [PDF]
, 2017 Complexity theory has been used to study a wide range of systems in biology and nature but also business and socio-technical systems, e.g., see [1].
Moschoyiannis, Sotiris +1 more
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Annales Academiae Medicae SilesiensisIntroduction: Heart failure with preserved ejection fraction (HFpEF) is characterized by left ventricle (LV) diastolic dysfunction. Impaired diastolic function induces pulmonary congestion and leads to postcapillary pulmonary hypertension (PH), which is ...
Julia Dołęga +6 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Analysis of the monitoring network of substation as a complex network
, 2013 The electrical equipments as the most important part in the Substation need to be monitored usually. Here we study the network of Substation, which represents the distribution of state monitoring equipments in the Substation, as a complex network.
Zhang HY(张宏宇) +4 more
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Complex Network Traffic Signal Optimized Model and Simulation
, 2015 In urban road traffic system, an important issue with the expansion of the network, resulting in the increasing complexity of the network, in-depth analysis of complex network operating mechanism is to further optimize and control network traffic and ...
Bi X(毕欣) +3 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source