Results 101 to 110 of about 18,147,174 (321)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Intelligent Anti-Jamming Decision-Making Technology Based on Knowledge Graph and DQN
SensorsRecent advancements in artificial intelligence have driven significant progress in intelligent anti-jamming communications. However, existing methods still face two major limitations: reinforcement learning-based models often suffer from slow convergence,
Dadong Ni +6 more
doaj +1 more source
Modelling the Self-similarity in Complex Networks Based on Coulomb's Law [PDF]
, 2014 Recently, self-similarity of complex networks have attracted much attention. Fractal dimension of complex network is an open issue. Hub repulsion plays an important role in fractal topologies.
Deng, Yong +4 more
core
A complex network approach to clinical science
European Journal of Clinical Investigation, 2018 Contemporary classification systems assume that psychiatric disorders are expressions of latent disease entities. However, some critics point to the comorbidity problem and other issues that question the validity of the latent disease model.
S. Hofmann, Joshua E. Curtiss
semanticscholar +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Predicting synthetic rescues in metabolic networks
Molecular Systems Biology, 2008 An important goal of medical research is to develop methods to recover the loss of cellular function due to mutations and other defects. Many approaches based on gene therapy aim to repair the defective gene or to insert genes with compensatory function.
Adilson E Motter +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Analyzing Trails in Complex Networks
, 2007 Even more interesting than the intricate organization of complex networks are the dynamical behavior of systems which such structures underly. Among the many types of dynamics, one particularly interesting category involves the evolution of trails left ...
E. Bonabeau +6 more
core +1 more source
Spectral entropies as information-theoretic tools for complex network comparison [PDF]
, 2016 Any physical system can be viewed from the perspective that information is implicitly represented in its state. However, the quantification of this information when it comes to complex networks has remained largely elusive.
M. Domenico, J. Biamonte
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source