Results 111 to 120 of about 10,677,913 (302)

Complex Network Traffic Signal Optimized Model and Simulation

, 2015
In urban road traffic system, an important issue with the expansion of the network, resulting in the increasing complexity of the network, in-depth analysis of complex network operating mechanism is to further optimize and control network traffic and ...
Bi X(毕欣), Du JS(杜劲松), Zhao YN(赵越南), Wang W(王伟)   +3 more
core  

From thread to yarn, and yarn to thread: a complex case of persistent left superior vena cava

Annales Academiae Medicae Silesiensis
Introduction: Persistent left superior vena cava (PLSVC) is a rare venous anomaly, occurring in 0.3–0.5% of the general population and up to 4.3% of patients with heart defects. It forms from the junction of the left subclavian and internal jugular veins,
Julia Dołęga, Natalia Lekston, Karolina Krzywiecka, Aleksandra Machnik, Katarzyna Mizia-Stec   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Catholic Women's Network, May / June, 1993

, 1993
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core  

A generalized logistic-logit function and its application to multi-layer perceptron and neuron segmentation

Frontiers in Artificial Intelligence
Logistic and logit functions play important roles in modern science, serving as foundational tools in various applications, such as artificial neural networks (ANN).
Wenqi Gu, Wenqi Gu, Yingtao Zhang, Yingtao Zhang, Alessandro Muscoloni, Alessandro Muscoloni, Carlo Vittorio Cannistraci, Carlo Vittorio Cannistraci, Carlo Vittorio Cannistraci   +8 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Prognostic role of exercise intensity in familial Filamin C truncating variants

Open Heart
Background Truncating variants in the Filamin C (FLNCtv) gene are causative of highly arrhythmogenic cardiomyopathies. Guidelines remain controversial concerning competitive and high-intensity sports for FLNCtv carriers.
Flavio Luciano Ribichini, Marta Gigli, Marco Merlo, Gianfranco Sinagra, Luisa Mestroni, Matteo Dal Ferro, Maria Perotto, Irena Tavčar, Martina Setti, Giulio Savonitto, Alessia Paldino, Samuel Furlan   +11 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source