Results 141 to 150 of about 1,032,211 (315)
Unsupervised Clustering of Cities Using Commercial Air Traffic: A Proxy for Economic Connectivity
MathematicsThis paper proposes a data-driven framework to identify and rank economically connected cities by using commercial air traffic as a proxy for urban economic connectivity. The study is motivated by the limitation of traditional city classifications, which
Sergio Iglesias-Perez +3 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Symmetry breaking in optimal transport networks
Nature CommunicationsEngineering multilayer networks that efficiently connect sets of points in space is a crucial task in all practical applications that concern the transport of people or the delivery of goods.
Siddharth Patwardhan +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Diffusion processes within 2D complex networks [PDF]
reservedDiffusion governs the dynamics of a wide range of physical, chemical, and biological systems. While classical Brownian motion provides a framework for standard diffusion, many heterogeneous and crowded environments give rise to anomalous ...
FACCA, GIANLUCA
core
Cluster damage robustness analysis and space independent community detection in complex networks [PDF]
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis investigates the evolution of two very different complex systems using network theory. This multi-disciplinary technique is widely used to model
Gegov, Emil
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source