Results 141 to 150 of about 7,591,420 (248)
Variational principles for hierarchical and modular architectures in complex networks
reservedThe structure of real-world networks often reflects a balance between efficient information integration and the preservation of functional diversity.
CERNI, PAOLO LAPO
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Detection of Four-Node Motif in Complex Networks
, 2017 Complex network analysis has gained research interests in a wide range of fields. Network motif, which is one of the most popular network properties, is a statistically significant network subgraph.
Feng Xia +7 more
core +1 more source
Sameness entices, but novelty enchants in fanfiction online
Humanities & Social Sciences CommunicationsCultural evolution is driven by how we choose what to consume and share with others. A common belief is that the cultural artifacts that succeed are the ones that balance novelty and conventionality.
Elise Jing +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Infection spreading, detection and control in community networks
, 2017 Community structures widely exist in various complex networks. Extensive studies have been carried out on defining and quantifying community structures as well as developing algorithms for detecting them in extra-large complex systems.
Xiao, Gaoxi, Yu, Yi
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
V Mediterranean School of Complex Networks
, 2019 With its fifth edition, the Mediterranean School of Complex Networks is one of the oldest international summer schools, run without interruptions, which is fully devoted to teach the fundamentals of Network Science and its current trends to early-career ...
A. Arenas, M. De Domenico
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
LumbriCyc: towards metabolic modelling of earthworms
npj Systems Biology and ApplicationsUntil Charles Darwin published his book on earthworms in 1881, their role in the soil was largely unclear. By now, the importance of earthworms for soil fertility has been recognized and their phenomenology is being studied for various purposes.
Axel von Kamp
doaj +1 more source