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Predicting skin permeability from complex chemical mixtures

Toxicology and Applied Pharmacology, 2005
Occupational and environmental exposure to topical chemicals is usually in the form of complex chemical mixtures, yet risk assessment is based on experimentally derived data from individual chemical exposures from a single, usually aqueous vehicle, or from computed physiochemical properties.
Jim E, Riviere, James D, Brooks
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Complex Magnetic Permeability of Spherical Particles

Proceedings of the IRE, 1953
The effective complex magnetic permeability of an array of spherical conducting permeable particles is computed. Curves are presented which illustrate the dependence of the conductivity, permeability and radius of the particle and the frequency.
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Improving permeability and oral absorption of mangiferin by phospholipid complexation

Fitoterapia, 2014
Mangiferin is an active ingredient of medicinal plant with poor hydrophilicity and lipophilicity. Many reports focused on improving aqueous solubility, but oral bioavailability of mangiferin was still limited. In this study, we intended to increase not only solubility, but also membrane permeability of mangiferin by a phospholipid complexation ...
Hequn, Ma   +4 more
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Complex Permeability of Ferrites Correlated with their Microstructure

Advances in Science and Technology, 2006
The totality of spinel and garnet polycrystalline ferrite (PF) samples is divided in two subgroups in process of their complex initial permeability (including the static value) relating to their microstructure (MS). The analysis for the first, including PF of rather perfect MS brings to explicit relations showing the effects of grain size distribution.
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An Equivalent Complex Permeability Model for Litz-Wire Windings

IEEE Transactions on Industry Applications, 2005
Previous methods for calculating power loss in litz-wire windings usually assume very fine strands such that the diameter of strands is much smaller than skin depth. In this paper, we present a method for calculating proximity-effect loss in litz-wire windings.
null Xi Nan, C.R. Sullivan
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Membrane permeability to macromolecules mediated by the membrane attack complex

Biochemistry, 1989
A simple and well-defined system of purified phospholipids and human complement proteins was used to study membrane permeability to macromolecules mediated by the membrane attack complex (MAC) of complement. Large unilamellar vesicles (LUVs) of phosphatidylcholine (PC) or phosphatidylserine (PS) containing trapped macromolecules [bovine pancreatic ...
J A, Malinski, G L, Nelsestuen
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Structural requirement for duodenal permeability of heparin-diamine complexes

Biochimica et Biophysica Acta (BBA) - General Subjects, 1992
We have compared the physico-chemical behaviors alone and in the presence of a synthetic bilayer membrane, in aqueous solution and the bioavailability after intraduodenal administration to rabbits, of the two heparin diamine salts ITF-300 and ITF-331 with those of the heparin-amine salt ITF-1175.
G, Zoppetti   +3 more
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On the Role of the Respiratory Complex I on Membrane Permeability Transition

Journal of Bioenergetics and Biomembranes, 2005
In this work we studied permeability transition by incubating mitochondria in the presence of 50 muM Ca(2+) and malate/glutamate as substrates. This condition, besides inducing the release of pyridine nucleotides, promotes the generation of reactive oxygen-derived species by the complex I of the respiratory chain. The latter leads to the opening of the
Noemí, García   +2 more
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Complex redundancy to build a simple epidermal permeability barrier

Current Opinion in Cell Biology, 2003
To survive the transition from an aqueous in utero to a terrestrial ex utero environment, mice and humans must construct an epidermal permeability barrier in utero. Terminally differentiated epidermal cells, lipids and tight junctions are all essential to achieve this barrier.
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Water Permeability Measurement in Living Cells and Complex Tissues

Journal of Membrane Biology, 2000
The identification of molecular water transporters and the generation of transgenic mice lacking water transporting proteins has created a need for accurate methods to measure water permeability. This review is focused on methodology to characterize water permeability in living cells and complex multicellular tissues.
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