Results 41 to 50 of about 751,293 (281)

The selective permeability barrier in the nuclear pore complex [PDF]

Nucleus, 2016
The nuclear pore complex (NPC) mediates the shuttle transport of macromolecules between the nucleus and cytoplasm in eukaryotic cells. The permeability barrier formed by intrinsically disordered phenylalanine-glycine-rich nucleoporins (FG-Nups) in the NPC functions as the critical selective control for nucleocytoplasmic transport.
Christina, Li, Alexander, Goryaynov, Weidong, Yang   +2 more
openaire   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Experimental study of the permeability of fractured sandstone under complex stress paths

Energy Science & Engineering, 2020
Oil and gas are main storage resources in the pores and fractures of rocks. Under a complex stress environment, the permeability evolution of the reservoir rock fracture directly affects the flow of oil and gas, which is important in oil and gas ...
Yu Zhang, Lu Wang, Hao Li, Yan Zhang, Guangming Fu   +4 more
doaj   +1 more source

Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media

Pharmaceutics, 2022
The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of ...
Dong Ye, Álvaro López Mármol, Verena Lenz, Patricia Muschong, Anita Wilhelm-Alkubaisi, Manuel Weinheimer, Mirko Koziolek, Kerstin A. Sauer, Loic Laplanche, Mario Mezler   +9 more
doaj   +1 more source

Complex permeability of polycrystalline Mn-Zn and Ni-Zn ferrites

Electrical Engineering in Japan, 1997
The complex permeability of ferrites is frequency dependent. The real part of the complex permeability deteriorates in a high frequency range and the imaginary part has a peak after starting the deterioration. This paper examines the possibility that the frequency characteristics for some ferrites can be approximately derived from a first-order linear ...
Hideo Saotome, Yo Sakaki
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Frequency dependence of microwave complex permeability under magnetic bias

EPJ Web of Conferences, 2018
Measurement of the frequency dependence of the permeability under magnetic bias is proposed as a new method for studying the microwave magnetic properties of magnetic materials.
Shiryaev Artem O., Bobrovskii Stanislav Y., Osipov Aleksey V., Petrov Dmitry A., Rozanov Konstantin N., Starostenko Sergey N.   +5 more
doaj   +1 more source

Quantitative Characterization of Heterogeneity in Different Reservoir Spaces of Low-Permeability Sandstone Reservoirs and Its Influence on Physical Properties

Advances in Civil Engineering, 2021
The complex pore structure of low-permeability sandstone reservoir makes it difficult to characterize the heterogeneity of pore throat. Taking the reservoir of Sanjianfang formation in QL oilfield as an example, the fractal dimension of different storage
Fengjuan Dong, Na Liu, Zhen Sun, Xiaolong Wei, Haonan Wang, Junxiang Nan, Dazhong Ren   +6 more
doaj   +1 more source

Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency [PDF]

Nature Communications, 2016
AbstractMitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of diseases includes serious or fatal neurological presentations such as Leigh syndrome and there are very limited evidence-based treatment options available.
Johannes K. Ehinger, Sarah Piel, Rhonan Ford, Michael Karlsson, Fredrik Sjövall, Eleonor Åsander Frostner, Saori Morota, Robert W. Taylor, Doug M. Turnbull, Clive Cornell, Steven J. Moss, Carsten Metzsch, Magnus J. Hansson, Hans Fliri, Eskil Elmér   +14 more
openaire   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source