Results 61 to 70 of about 750,698 (280)

The Study of the Influence of Formulation and Process Variables on the properties of Simvastatin-Phospholipid Complex [PDF]

, 2016
Objectives: The aim of the present study was to examine the influence of the formulation and process variables on the entrapment efficiency of simvastatin-phospholipid complex (SPC), prepared with a goal of improving the solubility and permeability of ...
Belgamwar, Veena S., Dave, Vivek S, Dharashivkar, Sanket S., Mack, Connor, Rode, Aniket A., Saoji, Suprit   +5 more
core   +1 more source

Cell‐Permeable β‐Peptide Inhibitors of p53/hDM2 Complexation [PDF]

ChemBioChem, 2009
AbstractLook at what the cat(ionic motif) dragged in! We report a general strategy to increase the cell permeability of β3‐peptides. Introduction of a minimal cationic motif within the folded structure of a high‐affinity β3‐peptide ligand for hDM2 led to molecules with high 314‐helical structure, high hDM2 affinity and sufficient cell permeability to ...
Elizabeth A, Harker, Alanna, Schepartz
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Design of coaxial aircell fixture for the measurement of electromagnetic properties

Journal of Microwaves, Optoelectronics and Electromagnetic Applications
Coaxial aircells are designed and fabricated to measure the electromagnetic properties of ferrite materials in the frequency range from 1 MHz to 3.6 GHz.
V. Seetha Rama Raju
doaj   +1 more source

Self-similar shock wave solutions of the non-linear Maxwell equations

, 2014
In our study we consider nonlinear, power-law field-dependent electrical permitivity and magnetic permeability and investigate the time-dependent Maxwell equations with the self-similar Ansatz.
Barna, I. F.
core   +1 more source

Complex permeability spectra of permendur composite materials

Journal of Physics: Conference Series, 2010
Complex permeability μ* and permittivity * spectra of permendur (Co50Fe50) composite materials have been studied in the microwave frequency range considering the application to the left-handed meta-materials and EMC devices. High surface electrical resistance of the permendur particles was achieved by the heat-treatment in order to suppress the eddy ...
Teruhiro Kasagi, Takanori Tsutaoka, Kenichi Hatakeyama   +2 more
openaire   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Dynamic reservoir-condition microtomography of reactive transport in complex carbonates: effect of initial pore structure and initial brine pH [PDF]

, 2017
We study the impact of brine acidity and initial pore structure on the dynamics of fluid/solid reaction at high Péclet numbers and low Damköhler numbers.
Bijeljic, B, Blunt, M, Menke, HP
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source