Results 81 to 90 of about 5,831,128 (302)

Mathematical modeling of the filtration flows movement in contaminated wells [PDF]

E3S Web of Conferences
Within the framework of this article, examples of solving specific problems related to the flow of fluid to a well in basin conditions and the flow of groundwater in limited layers, affecting environmental pollution, are considered.
Petrov Nikolay P., Petrova Svetlana N., Korzhavina Natalya V.   +2 more
doaj   +1 more source

Performance of two complementary machine-learned potentials in modelling chemically complex systems

npj Computational Materials, 2023
Chemically complex multicomponent alloys possess exceptional properties derived from an inexhaustible compositional space. The complexity however makes interatomic potential development challenging. We explore two complementary machine-learned potentials—
Konstantin Gubaev, Viktor Zaverkin, Prashanth Srinivasan, Andrew Ian Duff, Johannes Kästner, Blazej Grabowski   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action [PDF]

, 1987
1. Intracellular recordings were obtained from neurones in layers 2 and 3 of the rat frontal neocortex in an in vitro slice preparation. Three distinct types of stimulation-evoked post-synaptic potentials were recorded in these neurones: excitatory post ...
Howe, James R., Zieglgänsberger, Walter, J R Howe, B Sutor, Sutor, Bernd, W Zieglgänsberger   +5 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Biophysics of Extracellular Action Potentials [PDF]

, 2007
The goal of this thesis is to analyze the generation of single unit extracellular action potentials (EAPs), and to explore pertinent issues in the interpretation of EAP recordings.
Gold, Carl
core   +1 more source

Viscoelastic State of an Anisotropic Plate with a Single Elliptic Inclusion

Journal of Mechanical Engineering
The linear viscoelasticity problem for an infinite anisotropic plate with an elliptical elastic inclusion under ideal mechanical contact conditions is solved. To obtain the solution, the small parameter method is applied, where the variation of Poisson's
Andrii O. Koshkin, Olena O. Strelnikova
doaj   +1 more source

Harmonic trap method for complex short-range potentials

Physics Letters B
The trap method has been successfully applied in the nuclear community to address scattering problems involving particles interacting through real potentials.
Hantao Zhang, Dong Bai, Zhongzhou Ren
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source