Results 61 to 70 of about 956,090 (356)

Integrable matrix models in discrete space-time

SciPost Physics, 2020
We introduce a class of integrable dynamical systems of interacting classical matrix-valued fields propagating on a discrete space-time lattice, realized as many-body circuits built from elementary symplectic two-body maps.
Žiga Krajnik, Enej Ilievski, Tomaž Prosen
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Higher-spin self-dual Yang-Mills and gravity from the twistor space

Journal of High Energy Physics, 2023
We lift the recently proposed theories of higher-spin self-dual Yang-Mills (SDYM) and gravity (SDGR) to the twistor space. We find that the most natural room for their twistor formulation is not in the projective, but in the full twistor space, which is ...
Yannick Herfray, Kirill Krasnov, Evgeny Skvortsov   +2 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Isotropic Lagrangian Submanifolds in Complex Space Forms [PDF]

Journal of Sciences, Islamic Republic of Iran, 2012
In this paper we study isotropic Lagrangian submanifolds , in complex space forms . It is shown that they are either totally geodesic or minimal in the complex projective space , if . When , they are either totally geodesic or minimal in .
M.B. Kashani
doaj  

Toeplitz Operators, Pseudo-Homogeneous Symbols, and Moment Maps on the Complex Projective Space

Journal of Function Spaces, 2017
Following previous works for the unit ball due to Nikolai Vasilevski, we define quasi-radial pseudo-homogeneous symbols on the projective space and obtain the corresponding commutativity results for Toeplitz operators. A geometric interpretation of these
Miguel Antonio Morales-Ramos, Raul Quiroga-Barranco, Armando Sanchez-Nungaray   +2 more
doaj   +1 more source

Immersions of real projective spaces into complex projective spaces

Hiroshima Mathematical Journal, 1987
This paper achieves a classification up to regular homotopy of immersions from a real projective space \(P^ n({\mathbb{R}})\) into a complex projective space \(P^ m({\mathbb{C}})\). Calculations with characteristic classes show that, for \(n>m\), any such immersion is nullhomotopic.
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Quadratic Killing tensors on symmetric spaces which are not generated by Killing vector fields

Comptes Rendus. Mathématique
Every Killing tensor field on the space of constant curvature and on the complex projective space can be decomposed into the sum of symmetric tensor products of Killing vector fields (equivalently, every polynomial in velocities integral of the geodesic ...
Matveev, Vladimir S., Nikolayevsky, Yuri
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source