Results 131 to 140 of about 8,967,370 (295)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Séance 3 - Lutter, se défendre : la non-violence en question
, 2019 Jeudi 12 décembre | 17 h [séance reportée] Salle Pierre Albouy Université Paris Diderot - Grands Moulins (6e étage) - 5 rue Thomas Mann 75013 Paris Au cours de cette séance, nous présenterons et discuterons des textes de divers.es auteur.e.s,
La question de la violence
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Education SciencesDeveloping higher-order thinking skills in general, and question-asking skills in particular, is considered a cornerstone for fostering critical and cognitive thinking skills.
Riam Abu Much, Aya Deeb
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
[Violence et sommeil] Veiller la nuit, dormir debout
, 2020 Dormir. Que voudrait dire « dormir », « ne pas dormir », pas seulement la nuit mais dans le creux de l’Histoire, au cœur des événements, de leur violence ?
La question de la violence
core
Statistical learning of complex questions
, 2010 The problem of auxiliary fronting in complex polar questions occupies a prominent position within the nature versus nurture controversy in language acquisition. We employ a model of statistical learning which uses sequential and semantic information to produce utterances from a bag of words.
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Remote Ischemic Preconditioning: A Complex Question with an Even More Complex Answer. [PDF]
Semin Thorac Cardiovasc Surg, 2018 Schubert SA, Kron IL.
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source