Results 141 to 150 of about 5,245,414 (245)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Roadmap on singular optics and its applications. [PDF]

Appl Phys B
Balasubramaniam GM, Allam SR, Anand V, Ansari MH, Arockiaraj FG, Arnon S, Badavath PS, Baliyan M, Bouchal P, Bouchal Z, Choudhary S, Dorrah AH, Duan Y, Everts K, Forbes A, Foreman MR, Gailevičius D, Gautam A, Gbur G, Gopinath S, Joshi N, Juodkazis S, Korotkova O, Kukli K, Kupferman J, Kumar P, Kumar R, Kumar V, Manavalan G, Mehra A, Nishchal NK, Omatsu T, Peters C, Reddy ANK, Reddy SG, Rodríguez-Fajardo V, Rosales-Guzmán C, Rosen J, Sarita, Shikder A, Singh RK, Su X, Tamm A, Velagala G, Viewegh P, Vilardell EP, Willner AE, Xavier API, Yadav A, Zhou H.   +49 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Spatiotemporal dynamics of scattering exceptional points. [PDF]

Nat Commun
Xiao Y, Che Z, Shi L, Wang X, Zhu J.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Transformation Equivalence of Neural Networks. [PDF]

Entropy (Basel)
Kobayashi M.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Multifractal Analysis of Ion-Channel Currents: A Comparative Study of the WTMM and MFDFA Approaches. [PDF]

Membranes (Basel)
Miśkiewicz J, Burdach Z, Siemieniuk A, Karcz W.   +3 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Exact Solution and Large-Scale Scaling Analysis of the Imaginary Creutz-Stark Ladder. [PDF]

Entropy (Basel)
Qi Y, Lin H, Lu Q, Long D, Ruan D, Long GL.   +5 more
europepmc   +1 more source