Results 131 to 140 of about 5,837 (259)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The transverse singular complex

Let $M$ be a smooth manifold without boundary and let $\mathcal{T}$ be a countable collection of manifolds with corners, each equipped with a smooth map to $M$. We show that the singular simplicial set $\mathrm{Sing}(M)$ of $M$ deformation retracts onto the simplicial subset $\mathrm{Sing}^{\mathcal{T}}\!(M)$ of smooth singular simplices that are ...
Friedman, Greg, Medina-Mardones, Anibal M., Sinha, Dev   +2 more
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Classification of Real Solutions of the Fourth Painlevé Equation

Mathematics
Painlevé transcendents are usually considered as complex functions of a complex variable, but, in applications, it is often the real cases that are of interest.
Jeremy Schiff, Michael Twiton
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Topology of non-isolated singularities of complex surfaces

, 2019
Milnor fibers play a crucial role in the study of the topology of a singularity of surface. They correspond to the different possible smoothings of this singularity. A description of this fiber is known in some particular cases, but in general it is not,
Curmi, Octave
core  

On the propagation of isotropic Sobolev singularities

Bruno Pini Mathematical Analysis Seminar
The aim of these notes is to examine the propagation of isotropic Sobolev (micro)singularities for an evolution problem whose generator is given by the Weyl quantization of a complex-valued quadratic form on phase space.
Marcello Malagutti, Alberto Parmeggiani, Davide Tramontana   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Multiplicity of singularities as bi-Lipschitz invariant

, 2019
We prove that multiplicity of complex analytic singularities of dimension $d$ is invariant under bi-Lipschitz homeomorphisms if, and only if, $d=1$ or $d=2$. This result was obtained in joint works with J. de Bobadilla, J. E. Sampaio. and L. Birbrair, J.
Fernandes, Alexandre
core  

Numerical Solutions of Fractional Weakly Singular Two-Dimensional Partial Volterra Integral Equations Using Euler Wavelets

Mathematics
This paper presents an innovative numerical method for solving two-dimensional weakly singular Volterra integral equations, including fractional Volterra integral equations with weak singularities.
Seyed Sadegh Gholami, Ali Ebadian, Amirahmad Khajehnasiri, Kareem T. Elgindy   +3 more
doaj   +1 more source