Results 81 to 90 of about 1,217,820 (328)

A cracked orthotropic sheet stiffened by a semi-infinite orthotropic sheet [PDF]

The stress intensity factor is determined for a cracked orthotropic sheet adhesively bonded to an orthotropic stringer. Since the stringer is modeled as a semiinfinite sheet, the solution is most appropriate for a crack tip located near a stringer edge ...
Bigelow, C. A.
core   +1 more source

The psychological impact of motor vehicle accidents : a New Zealand study : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Psychology at Massey University [PDF]

, 1997
PLEASE NOTE Pages 72-73 are missing from the original copyThe present research attempted to identify those factors which predispose victims of severe motor vehicle accidents to develop PTSD, and explored the relationship between mental health and health ...
Kennedy-Moffat, James
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Risk Factors for Stress Fractures in Athletes

Quality in Sport
Introduction Stress fractures can affect up to 10% of athletes, with amateurs who exhibit high levels of ambition being particularly at risk.
Aleksandra Minda, Barbara Anna Zapalska, Antonina Teresa Witkowska, Julia Piotrowska, Aleksandra Łubińska-Kowalska, Adrianna Domańska, Adrianna Witkowska, Monika Wendland, Krzysztof Julian Długosz, Justyna Janikowska   +9 more
doaj   +1 more source

Stress and periodontal disease: The link and logic!!

Industrial Psychiatry Journal, 2013
Stress is an equated response to constant adverse stimuli. At one point or another everybody suffers from stress. Stress is compatible with good health, being necessary to cope with the challenges of everyday life. Problems start when the stress response
Sachin Goyal, Garima Gupta, Betsy Thomas, K M Bhat, G S Bhat   +4 more
doaj   +1 more source

Stress-intensity factor calculations using the boundary force method [PDF]

The Boundary Force Method (BFM) was formulated for the three fundamental problems of elasticity: the stress boundary value problem, the displacement boundary value problem, and the mixed boundary value problem.
Newman, J. C., Jr., Raju, I. S., Tan, P. W.   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Stress Concentrations in Non-Homogeneous Elastic Layer Weakened by Cracks

Engineering Transactions, 1979
The paper presents the statical problem of stress concentrations around the tips of two semi-infinite cracks situated within an infinite, non-homogenous elastic layer. The conditions of antiplane state of strain are assumed to be satisfied.
M. Matczyński
doaj