Results 181 to 190 of about 13,893,592 (304)

High-resolution cryo-EM of a small protein complex: The structure of the human CDK-activating kinase.

The human CDK-activating kinase (CAK) is a multifunctional protein complex and key regulator of cell growth and division. Because of its critical functions in regulating the cell cycle and transcription initiation, it is a key target for multiple cancer ...
Greber, BJ
core   +1 more source

High-efficiency electro-Fenton mineralization of triclosan using a novel octahedral iron(iii) complex: structure, mechanism, and performance. [PDF]

RSC Adv
Rabaaoui N, Guesmi A, Jabeur W, Mhadhbi N, Ben Hamadi N, Khezami L, Cherif M, Naïli H.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

High-accuracy protein complex structure modeling based on sequence-derived structure complementarity. [PDF]

Nat Commun
Hou M, Xia Y, Wang P, Lv Z, Hou D, Zhou X, Zeng J, Zhang G.   +7 more
europepmc   +1 more source

Partition complex structure can arise from sliding and bridging of ParB dimers. [PDF]

Nat Commun, 2023
Connolley L, Schnabel L, Thanbichler M, Murray SM.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Bioactivity Deep Learning for Complex Structure-Free Compound-Protein Interaction Prediction. [PDF]

J Chem Inf Model
Gu Y, Xia S, Ouyang Q, Zhang Y.
europepmc   +1 more source

Coordinatively Unsaturated Nickel Nitroxyl Complex: Structure, Physicochemical Properties, and Reactivity toward Dioxygen. [PDF]

Molecules, 2023
Fujisawa K, Kataoka T, Terashima K, Kurihara H, de Santis Gonçalves F, Lehnert N.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Improving AlphaFold2- and AlphaFold3-Based Protein Complex Structure Prediction With MULTICOM4 in CASP16. [PDF]

Proteins
Liu J, Neupane P, Cheng J.
europepmc   +1 more source