Results 191 to 200 of about 8,195,688 (291)

SnapShot: Mediator complex structure. [PDF]

Cell, 2022
Nayak S, Taatjes DJ.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Construction of PROTAC-Mediated Ternary Complex Structure Distribution Profiles Using Extensive Conformational Search. [PDF]

J Chem Inf Model
Kudo G, Hirao T, Harada R, Shigeta Y, Hirokawa T, Yoshino R.   +5 more
europepmc   +1 more source

Long-read sequencing reveals the complex structure of extra dic(21;21) chromosome and its biological effects. [PDF]

Hum Genet, 2023
Yoshida-Tanaka K, Ikemoto K, Kuribayashi R, Unoki M, Takano T, Fujimoto A.   +5 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Insights into Catechin-Copper Complex Structure and Biologic Activity Modulation. [PDF]

Molecules
Lungu II, Cioanca O, Mircea C, Tuchilus C, Stefanache A, Huzum R, Hancianu M.   +6 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Advances and Challenges in Scoring Functions for RNA-Protein Complex Structure Prediction. [PDF]

Biomolecules
Zeng C, Zhuo C, Gao J, Liu H, Zhao Y.
europepmc   +1 more source

Effect of dye complex structure on performance in DSSCs; An experimental and theoretical study. [PDF]

Heliyon, 2022
Arjmand F, Rashidi Ranjbar Z, Fatemi E G H.   +2 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source