Results 91 to 100 of about 7,947,791 (315)

Out-of-equilibrium microcompartments for the bottom-up integration of metabolic functions

Nature Communications, 2018
Generating artificial cells able to carry out metabolic activities out-of-equilibrium is a current challenge in synthetic biology. Here the authors use a microfluidic platform for integration and analysis of minimal metabolic reactions in artificial ...
Thomas Beneyton, Dorothee Krafft, Claudia Bednarz, Christin Kleineberg, Christian Woelfer, Ivan Ivanov, Tanja Vidaković-Koch, Kai Sundmacher, Jean-Christophe Baret   +8 more
doaj   +1 more source

Complex systems science: expert consultation report [PDF]

, 2009
Executive SummaryA new programme of research in Complex Systems Science must be initiated by FETThe science of complex systems (CS) is essential to establish rigorous scientific principles on which to develop the future ICT systems that are critical to ...
Bourgine, Paul, Hales, David, Johnson, Jeffrey   +2 more
core  

Entropies for complex systems: generalized-generalized entropies

, 2007
Many complex systems are characterized by non-Boltzmann distribution functions of their statistical variables. If one wants to -- justified or not -- hold on to the maximum entropy principle for complex statistical systems (non-Boltzmann) we demonstrate ...
Andrea Rapisarda, Constantino Tsallis, Hans Herrmann, Piero Quarati, Rudolf Hanel, Stefan Thurner, Sumiyoshi Abe   +6 more
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

HPV transmission and optimal control of cervical cancer in China

Scientific Reports
Cervical cancer (CC), the fourth most common female malignancy globally, is predominantly caused by persistent infection with high-risk human papillomavirus (HPV) strains.
Huarong Ren, Rui Xu, Juan Zhang
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Evolution in complex systems

, 2004
What features characterise complex system dynamics? Power laws and scale invariance of fluctuations are often taken as the hallmarks of complexity, drawing on analogies with equilibrium critical phenomena[1-3]. Here we argue that slow, directed dynamics,
Bak, Bak, Bak, Boettcher, Christensen, Cohen, Cooper, Dall, Drossel, Drossel, Fischer, Hall, Helmstetter, Jensen, Jensen, Kauffman, Lee, Lenski, Newman, Nicodemi, Olami, Pruessner, Sibani, Sibani, Sornette, Ziemelis   +25 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Direct observation of a wakefield generated with structured light

Nature Communications
The use of structured light to control the phase velocity of the wake in laser-wakefield accelerators has generated significant interest for its ability to mitigate electron dephasing. Combining the diffraction-free properties of Bessel beams with spatio-
Aaron Liberman, Anton Golovanov, Slava Smartsev, Sheroy Tata, Igor A. Andriyash, Salome Benracassa, Eitan Y. Levine, Yang Wan, Eyal Kroupp, Victor Malka   +9 more
doaj   +1 more source