Results 91 to 100 of about 33,755,974 (386)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Studying complex adaptive systems using molecular classifier systems [PDF]
, 2007 Complex Adaptive Systems (CAS) are dynamical networks of interacting agents occurring in a variety of natural and artificial systems (e.g. cells, societies, stock markets). These complex systems have the ability to adapt, evolve and learn from experience.
Decraene, James +2 more
core
Complex Systems Research in Educational Psychology: Aligning Theory and Method
Educational Psychology, 2018 The purpose of this work is to provide an overview of complex systems research for educational psychologists. We outline a philosophically and theoretically sourced definition of complex systems research organized around complex, dynamic, and emergent ...
J. Hilpert, G. Marchand
semanticscholar +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
A decomposition of book structure through ousiometric fluctuations in cumulative word-time
Humanities & Social Sciences Communications, 2023 While quantitative methods have been used to examine changes in word usage in books, studies have focused on overall trends, such as the shapes of narratives, which are independent of book length.
Mikaela Irene Fudolig +4 more
doaj +1 more source
Connectivity and complex systems: learning from a multi-disciplinary perspective
Applied Network Science, 2018 In recent years, parallel developments in disparate disciplines have focused on what has come to be termed connectivity; a concept used in understanding and describing complex systems.
L. Turnbull +10 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Evolutionary Subnetworks in Complex Systems
, 2009 Links in a practical network may have different functions, which makes the original network a combination of some functional subnetworks. Here, by a model of coupled oscillators, we investigate how such functional subnetworks are evolved and developed ...
Bi G. Q. +4 more
core +1 more source
Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
Nature Communications, 2018 DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the ...
Sjors P. W. Wijnands +4 more
doaj +1 more source
Refractive plasma optics for relativistic laser beams
Nature Communications, 2023 The high intensities reached today by powerful lasers enable us to explore the interaction with matter in the relativistic regime, unveiling a fertile domain of modern science that is pushing far away the frontiers of plasma physics.
Omri Seemann +4 more
doaj +1 more source