Results 81 to 90 of about 15,720,626 (306)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Controlling protein activity by dynamic recruitment on a supramolecular polymer platform

Nature Communications, 2018
DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the ...
Sjors P. W. Wijnands, Wouter Engelen, René P. M. Lafleur, E. W. Meijer, Maarten Merkx   +4 more
doaj   +1 more source

Data-Driven Quality Assurance: Defect Prediction to Reduce Carbon Footprint in Manufacturing Logistics [PDF]

E3S Web of Conferences
In modern manufacturing environments, minimizing carbon emissions while maintaining product quality has become a strategic imperative. One critical yet often overlooked contributor to elevated CO₂ emissions is the occurrence of unexpected quality defects,
Douiri Rokaya, Taraa Chaymae, Elmoussami Haj, Ezzine Latifa   +3 more
doaj   +1 more source

Engineering complex systems [PDF]

Nature, 2004
The emergent properties of complex systems are far removed from the traditional preoccupation of engineers with design and purpose.
openaire   +2 more sources

Cooperation, Punishment, Emergence of Government, and the Tragedy of Authorities [PDF]

, 2012
Under the conditions prevalent in the late Pleistocene epoch (small hunter-gatherer groups and frequent inter-group conflicts), coevolution of gene-related behavior and culturally transmitted group-level institutions provides a plausible explanation ...
Vilela Mendes, Rui, Aguirre Maeso, Carlos   +1 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spliceator: multi-species splice site prediction using convolutional neural networks

BMC Bioinformatics, 2021
Background Ab initio prediction of splice sites is an essential step in eukaryotic genome annotation. Recent predictors have exploited Deep Learning algorithms and reliable gene structures from model organisms.
Nicolas Scalzitti, Arnaud Kress, Romain Orhand, Thomas Weber, Luc Moulinier, Anne Jeannin-Girardon, Pierre Collet, Olivier Poch, Julie D. Thompson   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Collective sleep and activity patterns of college students from wearable devices

npj Complexity
To optimize interventions for improving wellness, it is essential to understand habits that wearable devices can measure with greater precision. Using high temporal resolution biometric data taken from the Oura Gen3 ring, we examine daily and weekly ...
Mikaela Irene Fudolig, Laura S. P. Bloomfield, Matthew Price, Yoshi M. Bird, Johanna E. Hidalgo, Julia N. Kim, Jordan Llorin, Juniper Lovato, Ellen W. McGinnis, Ryan S. McGinnis, Taylor H. Ricketts, Kathryn Stanton, Peter Sheridan Dodds, Christopher M. Danforth   +13 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source