Results 81 to 90 of about 33,755,974 (386)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Mathematical control of complex systems [PDF]

open access: yes, 2013
Copyright © 2013 ZidongWang et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Hu, J, Karimi, HR, Shen, B, Wang, Z
core   +3 more sources

Forum: Complex Systems and International Governance

open access: yesInternational Studies Review, 2019
This collection of essays brings together scholars from various disciplinary backgrounds, based on three continents, with different theoretical and methodological interests but all active on the topic of complex systems as applied to international ...
Amandine J. Orsini   +10 more
semanticscholar   +1 more source

Complexity in the immune system [PDF]

open access: yesComputers & Chemical Engineering, 2005
25 pages, 12 ...
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Mechanisms in Dynamically Complex Systems [PDF]

open access: yes, 2011
In recent debates mechanisms are often discussed in the context of ‘complex systems’ which are understood as having a complicated compositional structure.
Kuhlmann, Meinard
core   +2 more sources

Complex Clients – Complex Systems?

open access: yesJANZSSA, 2000
I would like to start with a tale… Exposure 'Some time ago a clinical psychologist registrar noted, vexedly, that it was all very well knowing what her clients needed to do if they were to improve, but it was no use at all when they stubbornly refused ...
Tania Towers
doaj  

The shocklet transform: a decomposition method for the identification of local, mechanism-driven dynamics in sociotechnical time series

open access: yesEPJ Data Science, 2020
We introduce a qualitative, shape-based, timescale-independent time-domain transform used to extract local dynamics from sociotechnical time series—termed the Discrete Shocklet Transform (DST)—and an associated similarity search routine, the Shocklet ...
David Rushing Dewhurst   +6 more
doaj   +1 more source

Spliceator: multi-species splice site prediction using convolutional neural networks

open access: yesBMC Bioinformatics, 2021
Background Ab initio prediction of splice sites is an essential step in eukaryotic genome annotation. Recent predictors have exploited Deep Learning algorithms and reliable gene structures from model organisms.
Nicolas Scalzitti   +8 more
doaj   +1 more source

Are Innovation Systems Complex Systems?

open access: yes, 2016
Basically, complex systems are defined as a large number of autonomous entities in interaction, that create several levels of collective organization leading to emergent (and immergent) behavior. In short, complex systems are characterized by the observation that the whole is more than the sum of the parts (Aristotle).
Emmanuel Muller   +3 more
openaire   +4 more sources

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