Results 101 to 110 of about 2,018,314 (300)
Thinking Systemically About Complex Systems
Procedia Computer Science, 2013 AbstractAs machine age problems have given way to systems age messes, the underlying complexity associated with understanding these situations has increased exponentially. Accordingly, the methods we use to address these situations must evolve as well. Unfortunately, many antiquated methods for dealing with situations remain prominent.
Patrick T. Hester, Kevin MacG. Adams
openaire +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
, 2006 Ever since the word ‘ROBOT’ first appeared in a science\ud fiction in 1921, scientists and engineers have been trying\ud different ways to create it. Present technologies in\ud mechanical and electrical engineering makes it possible\ud to have robots in ...
Wang, Mr. L.
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Amazing Space: Cat's Eye Nebula (NGC 6543) Lithograph [PDF]
, 2005 This lithograph features Hubble Space Telescope images and includes text that describes and explains the images. There is also an accompanying inquiry-based classroom activity entitled “In Search of the Complex Structures of Planetary Nebulae.” This ...
Bonnie Eisenhamer
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Frontiers in EducationIntroductionThis study explores the transformative impact of Industry 4.0 on industrial operations, emphasizing the integration of advanced technologies like AI, IoT, and Big Data Analytics to enhance process optimization, automation, and connectivity ...
Ernesto Pacheco-Velazquez +2 more
doaj +1 more source
Developing the Management Competencies for Getting a Competitive Position in the Organic Food Market [PDF]
Although almost any conference tackles the issue of organic foods, we consider that this article does not fit into normal patterns of research. Our paper proposes a complex analysis in the field of organic food products.
Marian NASTASE +2 more
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