Results 191 to 200 of about 4,320,738 (271)

Factors associated with a complicated hospital course in patients with spontaneous coronary artery dissection: a report of the iSCAD registry. [PDF]

BMC Cardiovasc Disord
Alkhalfan F, Wood M, Leon K, Gibson CM, Chi G, Grodzinsky A, Gornik HL, Wells BJ, Lewey J, Taylor A, Kadian-Dodov D, Hess CN, Henkin S, Lindley KJ, Wells G, Orford JL, Tam L, Kumbhani DJ, Norris S, Reyes C, Vitarello C, Naderi S, Kim ES.   +22 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Congenital Gastrointestinal Malformations in a Romanian Tertiary Centre (2020-2024): A Retrospective Cohort Study of Diagnosis, Distribution, and Outcomes. [PDF]

Diagnostics (Basel)
Stratulat-Chiriac I, Chistol RO, Perianu L, Țarcă E, Țarcă V, Murgu AM, Popovici P, Halip IA, Cojocaru E, Chisălău V, Furnică C.   +10 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Intersection of paediatric heart disease and foster care status: a multicentre retrospective cohort study. [PDF]

BMJ Paediatr Open
Martens A, Gauvreau K, Smith T, Perez JM, Cox JE, Antonelli R, Shah SN, Newburger J, Moynihan KM.   +8 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Comorbidity severity adjusted model for predicting mortality in hospitalized patients with COPD. [PDF]

PLoS One
Seo JH, Lim JH.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Multi-Source Remote Sensing and Ensemble Learning for Habitat Suitability Mapping of the Common Leopard (<i>Panthera pardus</i>) in Azad Jammu and Kashmir, Pakistan. [PDF]

Sensors (Basel)
Dildar Z, Huang W, Ahmed R, Khalid Z.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source