Results 251 to 260 of about 7,641,584 (361)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Boron's Double Edge-Antibiotics, Toxins, and the Fine Line Between Them. [PDF]

Molecules
Dembitsky VM, Terent'ev AO, Baranin SV, Scorei IR.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Magnetically recoverable activated carbon/CMC-β-cyclodextrin composite sponge for high-performance Cr(VI) adsorption, reduction, and sustainable wastewater treatment. [PDF]

Sci Rep
Alhasani MA, Alatawi R, Sallam S, Al Zbedy AS, Jawhari AH, Alashqar S, Hameed AM, El-Metwaly NM.   +7 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

From Inclusion Complexes to Innovative Therapies: Cyclodextrins and Their Pharmaceutical Applications. [PDF]

Pharmaceutics
Trasca DM, Pirscoveanu DFV, Varut RM, Pluta ID, Stoica GA.   +4 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Deep Insight into Fine-Tuning the Structure Affecting the Extraction Sequence of Metal Cations by Phosphorylcarboxylic Acids: A Quantum Chemistry Study. [PDF]

ACS Omega
Zhang X, Zhang X, Du W, Liu X, Liao W.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Complexation of Citalopram with β‑Cyclodextrin, Mono-subetadex, and Subetadex: Phase Solubility, Hummel-Dreyer, Affinity Capillary Electrophoresis, ITC, and NMR Studies. [PDF]

ACS Omega
Ujj DV, Kasal P, Fejős I, Béni S, Kardos J, Benkovics G, Bálint E, Mátravölgyi B.   +7 more
europepmc   +1 more source