Results 171 to 180 of about 7,748,503 (383)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A novel qutrit representation for RGB digital images. [PDF]

Sci Rep
Rofail M, Montaser R, Younes A.
europepmc   +1 more source

Exponential separations in the energy complexity of leader election [PDF]

, 2017
Yi‐Jun Chang, Tsvi Kopelowitz, Seth Pettie, Ruosong Wang, Wei Zhan   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Ageing modulates the effects of scene complexity on visual search and target selection in virtual environments. [PDF]

R Soc Open Sci
Lachica IJ, Kalkar A, Finley JM.
europepmc   +1 more source

Low Complexity Cyclic Feature Recovery Based on Compressed Sampling

, 2015
Zhuo Sun, Jia Hou, Siyuan Liu, Sese Wang, Xuantong Chen   +4 more
openalex   +1 more source

Same Viewpoint Different Perspectives—A Comparison of Expert Ratings with a TLS Derived Forest Stand Structural Complexity Index [PDF]

, 2019
Julian Frey, Bettina Joa, Ulrich Schraml, Barbara Koch   +3 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Bridging the short-term and long-term dynamics of economic structural change. [PDF]

Nat Commun
McNerney J, Li Y, Gomez-Lievano A, Neffke F.   +3 more
europepmc   +1 more source

Exponential Separations in the Energy Complexity of Leader Election [PDF]

, 2019
Yi‐Jun Chang, Tsvi Kopelowitz, Seth Pettie, Ruosong Wang, Wei Zhan   +4 more
openalex   +1 more source