Results 61 to 70 of about 7,748,503 (383)

System-of-Systems Complexity

, 2013
The global availability of communication services makes it possible to interconnect independently developed systems, called constituent systems, to provide new synergistic services and more efficient economic processes.
Kopetz, Hermann
core   +2 more sources

The Koszul Complex is the Cotangent Complex [PDF]

International Mathematics Research Notices, 2011
23 ...
openaire   +3 more sources

Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1

FEBS Letters, EarlyView.
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji, Kosuke Shiraishi, Chuqian Wang, Hiroya Yurimoto, Yasuyoshi Sakai, Masahide Oku   +5 more
wiley   +1 more source

Complexity and Philosophy [PDF]

, 2006
The science of complexity is based on a new way of thinking that stands in sharp contrast to the philosophy underlying Newtonian science, which is based on reductionism, determinism, and objective knowledge.
Cilliers, Paul, Gershenson, Carlos, Heylighen, Francis   +2 more
core   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Complexity of Networks (reprise)

, 2011
Network or graph structures are ubiquitous in the study of complex systems. Often, we are interested in complexity trends of these system as it evolves under some dynamic.
Almunia, Baird, Baird, Barabási, Bedau, Caldarelli, Christian, Clauset, Claussen, Dewar, Dorin, Drossel, Duch, Görnerup, Jeong, Kim, Knuth, Layzer, Li, McKay, Monaco, Myrvold, Newman, Prigogine, Prokopenko, Ray, Standish, Standish, Standish, Standish, Standish, Standish, Standish, Standish, Watts, Wilhelm   +35 more
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Nonintegrability, Chaos, and Complexity

, 2000
Two-dimensional driven dissipative flows are generally integrable via a conservation law that is singular at equilibria. Nonintegrable dynamical systems are confined to n*3 dimensions.
Arnol'd, Arnol'd, Arnol'd, Bak, Bak, Bell, Bender, Bennett, Benzi, Bowler, Burns, Constantin, Constantin, Crisanti, Cvitanovic, de Sousa Viera, Eigen, Feigenbaum, Foias, Fornenko, Fredkin, Friedrich, Garey, Gleick, Grinstein, Gunaratne, Hu, Joseph L. McCauley, Koopman, Krug, Küppers, Lindley, Lipton, Lloyd, Lofse, Lorenz, McCauley, McCauley, McCauley, McCauley, McCauley, Moore, Moore, Moore, Morowitz, Olby, Olver, Omohundro, Poincaré, Ruelle, Schuster, She, Tabor, von Neumann, von Neumann, Weinberg, Wigner, Wintner, Young   +58 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source