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Cliopatria - A geospatial database of world-wide political entities from 3400BCE to 2024CE

Scientific Data
The scientific understanding of the complex dynamics of global history – from the rise and spread of states to their declines and falls, from their peaceful interactions with economic or diplomatic exchanges to violent confrontations – requires, at its ...
James S. Bennett, Erin Mutch, Andrew Tollefson, Ed Chalstrey, Majid Benam, Enrico Cioni, Jenny Reddish, Jakob Zsambok, Jill Levine, C. Justin Cook, Pieter Francois, Daniel Hoyer, Peter Turchin   +12 more
doaj   +1 more source

A Complex Lens for a Complex Eye [PDF]

Integrative and Comparative Biology, 2017
A key innovation for high resolution eyes is a sophisticated lens that precisely focuses light onto photoreceptors. The eyes of holometabolous larvae range from very simple eyes that merely detect light to eyes that are capable of high spatial resolution.
Aaron L, Stahl, Regina S, Baucom, Tiffany A, Cook, Elke K, Buschbeck   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Responsive Governance and Harmful Microbial Blooms on Lake Erie: An ABM Approach

, 2019
In general, decision makers tend to respond to problems rather than prevent them. In political science, this process of responsive governance is associated with complex dynamics such as availability cascades and punctuated equilibrium.
Pavlovich, Tyler, Webster, DG
core   +1 more source

Message from the editors [PDF]

, 2017
Complexity, Governance & Networks relaunches as an open access journal with a new publisher.
Morçöl, Göktuğ, Gerrits, Lasse, Göktuğ Morçöl, Lasse Gerrits   +3 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

On the complexity of linearizability [PDF]

Computing, 2015
It was shown in Alur et al. [1] that the problem of verifying finite concurrent systems through Linearizability is in EXPSPACE. However, there was still a complexity gap between the easy to obtain PSPACE lower bound and the EXPSPACE upper bound. We show in this paper that Linearizability is EXPSPACE-complete.
openaire   +6 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source