Results 71 to 80 of about 5,765,386 (368)

On Descriptive Complexity, Language Complexity, and GB [PDF]

, 1995
We introduce $L^2_{K,P}$, a monadic second-order language for reasoning about trees which characterizes the strongly Context-Free Languages in the sense that a set of finite trees is definable in $L^2_{K,P}$ iff it is (modulo a projection) a Local Set ...
Rogers, James
core   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Quantifying the impact of homophily and influencer networks on song popularity prediction

Scientific Reports
Forecasting the popularity of new songs has become a standard practice in the music industry and provides a comparative advantage for those that do it well. Considerable efforts were put into machine learning prediction models for that purpose.
Niklas Reisz, Vito D. P. Servedio, Stefan Thurner   +2 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Cliopatria - A geospatial database of world-wide political entities from 3400BCE to 2024CE

Scientific Data
The scientific understanding of the complex dynamics of global history – from the rise and spread of states to their declines and falls, from their peaceful interactions with economic or diplomatic exchanges to violent confrontations – requires, at its ...
James S. Bennett, Erin Mutch, Andrew Tollefson, Ed Chalstrey, Majid Benam, Enrico Cioni, Jenny Reddish, Jakob Zsambok, Jill Levine, C. Justin Cook, Pieter Francois, Daniel Hoyer, Peter Turchin   +12 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

The real life application of a procalcitonin-based algorithm to reduce antibiotic exposure in hospitalized patients with community acquired pneumonia: a proof of concept

Italian Journal of Medicine, 2016
Community-acquired pneumonia (CAP) represents a common cause of hospitalization in Internal Medicine wards and a frequent cause of antibiotic prescription.
Filippo Pieralli, Vieri Vannucchi, Maria Vittoria Silverii, Ezilda Ricci, Elena Fissi, Antonio Mancini, Francesca Bacci, Carlo Nozzoli   +7 more
doaj   +1 more source

Understanding Complexity [PDF]

, 2009
{Excerpt} In development agencies, paradigms of linear causality condition much thinking and practice. They encourage command-and-control hierarchies, centralize decision making, and dampen creativity and innovation.
Serrat, Olivier
core   +1 more source

Complexity in Cosmology

, 2001
The question of the nature of galaxy clustering and the possible homogeneity of galaxy distribution is one of the fundamental problem of cosmology.
Labini, Francesco Sylos, Pietronero, Luciano   +1 more
core   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source