Results 81 to 90 of about 5,924,258 (339)
The complexity of divisibility
Linear Algebra and its Applications, 2016 We address two sets of long-standing open questions in probability theory, from a computational complexity perspective: divisibility of stochastic maps, and divisibility and decomposability of probability distributions. We prove that finite divisibility of stochastic maps is an NP-complete problem, and extend this result to nonnegative matrices, and ...
Bausch, Johannes, Cubitt, Toby
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FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
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Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
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FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
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Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2010 This paper is concerned with complex macroscopic behaviour arising in many-body systems through the combinations of competitive interactions and disorder, even with simple ingredients at the microscopic level. It attempts to indicate and illustrate the richness that has arisen, in conceptual understanding, in methodology and in application, across a ...
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Protein kinase FAM20C—when subcellular localization matters
FEBS Letters, EarlyView.FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
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Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
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STUDIES WITH PURPLE ADENINE MUTANTS IN NEUROSPORA CRASSA. I. STRUCTURAL AND FUNCTIONAL COMPLEXITY IN THE AD-3 REGION [PDF]
, 1956 Frederick J. de Serres
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RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Revista Matemática Complutense, 2001 One considers a complex manifold \(M\) and its holomorphic tangent bundle \({\mathcal O}M\). First, the notion of \textit{complex spray} is defined following the usual notion of real spray as a homogeneous semispray. If \((z,v)=(z^{i},v^{i})\) are the local coordinates on \({\mathcal O}M\) then a complex spray \(X\) is expressed as \(X=v^{i}\frac ...
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