Results 91 to 100 of about 2,646,616 (265)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Community Networks and the Nature of Emergence in Civil Society

Cosmopolitan Civil Societies: An Interdisciplinary Journal, 2010
Our research challenges the limitations of extant knowledge of social formation by its focus on the ordinary, everyday lived reality of maintaining community and on identifying its operations from the internal perspective of civil society.
Jenny Onyx, Melissa Edwards
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Inviting systemic self-organization: Competencies for complexity regulation from a post-cognitivist perspective

Journal of Dynamic Decision Making
This contribution discusses competencies needed for regulating systems with properties of multi-causality and non-linear dynamics (therapeutic, economical, organizational, socio-political, technical, ecological, etc.).
Michael Kimmel
doaj   +1 more source

Prosperous teaching and the thing of darkness: Raising a Tempest in the classroom

Cogent Arts & Humanities, 2016
This essay uses Shakespeare’s The Tempest as a way of conceptualising modern institutional education. The over-systematisation of formal education which characterises professional teaching and learning in the twenty-first century is designated “SysEd ...
Liam E. Semler
doaj   +1 more source

Application of complexity theory in health and social care research: a scoping review. [PDF]

BMJ Open, 2023
Carroll Á, Collins C, McKenzie J, Stokes D, Darley A.   +4 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Quantitative Complexity Theory (QCT) in Integrative Analysis of Cardiovascular Hemodynamic Response to Posture Change. [PDF]

Life (Basel), 2023
Krzesiński P, Marczyk J, Wolszczak B, Gielerak GG, Accardi F.   +4 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Holographic subregion complexity in Einstein-Born-Infeld theory

European Physical Journal C: Particles and Fields, 2019
We numerically investigate the evolution of the holographic subregion complexity during a quench process in Einstein-Born-Infeld theory. Based on the subregion CV conjecture, we argue that the subregion complexity can be treated as a probe to explore the
Yi Ling, Yuxuan Liu, Cheng-Yong Zhang
doaj   +1 more source