Results 91 to 100 of about 8,702,509 (349)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Convex Isolating Clustering Centrality to Discover the Influential Nodes in Large Scale Networks

IEEE Access
Ranking influential nodes within complex networks offers invaluable insights into a wide array of phenomena ranging from disease management to information dissemination and optimal routing in real-time networking applications.
Buran Basha Mohammad, Sateeshkrishna Dhuli, Murali Krishna Enduri, Linga Reddy Cenkeramaddi   +3 more
doaj   +1 more source

Developing public service knowledge and learning about complex systems: using a community of practice to integrate theory and practice [PDF]

, 2018
A Community of Practice Knowledge Exchange (CPKE) comprising of practitioners and academics with an interest in complexity theory was formed. The central activity of the CPKE was an agreement that each would develop a case study that integrated ...
Haynes, Philip, Darking, Mary; id_orcid, Darking, Mary, Stroud, Julia, Julia Stroud, Philip Haynes, Mary Darking, Haynes, Philip; id_orcid   +7 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

An Overview of the Theory of Computational Complexity [PDF]

Journal of the ACM, 1971
The purpose of this paper is to outline the theory of computational complexity which has emerged as a comprehensive theory during the last decade. This theory is concerned with the quantitative aspects of computations and its central theme is the measuring of the difficulty of computing functions.
Juris Hartmanis, John E. Hopcroft
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Complexity theory for operators in analysis [PDF]

Proceedings of the forty-second ACM symposium on Theory of computing, 2010
We propose an extension of the framework for discussing the computational complexity of problems involving uncountably many objects, such as real numbers, sets and functions, that can be represented only through approximation. The key idea is to use a certain class of string functions as names representing these objects.
Akitoshi Kawamura, Stephen A. Cook
openaire   +3 more sources

Integrated System Responses for Families Impacted by Violence: A Scoping Review

International Journal of Integrated Care
Introduction: Violence within families is a complex problem which significantly impacts health and wellbeing. Despite the ubiquitous call for integrated family violence service delivery, integrated approaches vary significantly and challenges to ...
Claire Gear, Chien Ting, Carey Manuel, Elizabeth Eppel, Jane Koziol-McLain   +4 more
doaj   +1 more source