Results 121 to 130 of about 8,682,077 (303)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Implementing technological intelligence systems from the viewpoint of complexity theory

Ingeniería e Investigación, 2008
Technology currently plays a very important role in organisations’ development and competitiveness, thus requiring suitable handling. Technology management has been strengthened by integrating new systematically-applied concepts, such as technological ...
María Elena García Vergara, Óscar Fernando Castellanos Domínguez, Sonia Esperanza Monroy Varela   +2 more
doaj  

The Great Reset as a Realistic Utopia—A Critical Stance from Critical Realism and Complex Systems Theory

Systems
The Great Reset (GR) has been presented by the World Economic Forum (WEF) in response to the COVID-19 pandemic in 2022 as a model through which a “stakeholder economy” would achieve “resilient, equitable, and sustainable” social, economic, and ecological
Ermanno C. Tortia
doaj   +1 more source

A Critical Analysis of Industrial Human-Robot Communication and Its Quest for Naturalness Through the Lens of Complexity Theory. [PDF]

Front Robot AI, 2022
Mukherjee D, Gupta K, Najjaran H.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Three-Layered Psychological Analysis of an Epidemic: Impact and Legacy of Covid-19

International Journal of Psychoanalysis and Education, 2020
The global emergency caused by the spread of virus known as “Covid-19” caught many people by surprise, revealing the precariousness not only of health, but also of many other areas of our life, such as relationships, the economy, politics or the ...
Francesca Granier, Federica Pantaleo, Lorenzo Ielapi, Giorgio Soverchia   +3 more
doaj  

Use of complexity theory in health and social care: a scoping review protocol. [PDF]

BMJ Open, 2021
Carroll A, Stokes D, Darley A.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Complexity Theory

Computing Handbook, 3rd ed., 2019
Eric Allender, M. Loui, Kenneth W. Regan
semanticscholar   +2 more sources

Applying Complexity Theory to a Hospital Complex Patient Care Program. [PDF]

Int J Integr Care, 2021
Borghmans F, Fernandes V, Newnham H.
europepmc   +1 more source