Results 41 to 50 of about 1,101,795 (267)

Macroeconomic Determinants of Banks’ performance in Pakistan

International Journal of Experiential Learning & Case Studies, 2022
Almost all business operations that are now taking place in the economy may be impacted by recent changes in the macroeconomic indicators of the nation.
Hashir Ajaz, Faraz Ahmed, Yusra Shehzadi   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Modelo de gerenciamento de processos de negócio integrado ao gerenciamento de riscos para a melhoria do processo produtivo

Exacta, 2021
O mercado está cada vez mais competitivo e, por isso, as organizações têm adotado técnicas para garantir a própria sobrevivência. O Gerenciamento de Processos de Negócio (Business Process Management - BPM) vem sendo adotado por oferecer uma melhora ...
Paula Márcia da Silva Guimarães, José Luís Braga, Fernando Hadad Zaidan   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Compliance to Treatment

Clinical and Experimental Hypertension, 1993
One major challenge of hypertension management is to achieve a compliance rate as high as possible in order to guarantee a successful long-term antihypertensive therapy. Clinical studies have shown that the drop-out rate may represent an indirect parameter for patient compliance.
Schaub AF, Steiner A, Vetter W
openaire   +3 more sources

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Development of a Fully-Coupled, All States, All Hazards Level 2 PSA at Leibstadt Nuclear Power Plant

Nuclear Engineering and Technology, 2017
This paper describes the development process, the innovative techniques used and insights gained from the latest integrated, full scope, multistate Level 2 PSA analysis conducted at the Leibstadt Nuclear Power Plant (KKL), Switzerland.
Pavol Zvoncek, Olivier Nusbaumer, Alfred Torri   +2 more
doaj   +1 more source

Feminismo y Derecho Penal

Revista Justicia y Derecho, 2020
En el presente trabajo se pretende abordar cómo el feminismo ha influido en el Derecho Penal chileno, observando en primer lugar el fenómeno político del feminismo, considerando la gran fuerza que este movimiento ha tenido en Chile, para luego, en ...
Luis Hernán Acevedo Espínola
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source