Results 71 to 80 of about 3,290,407 (310)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Real-world insights on nutritional awareness and behaviors among preconception and pregnant women in three Asia Pacific countries

Frontiers in Global Women's Health
IntroductionIn many parts of Asia Pacific (APAC), insufficient intake of micronutrients that are important for conception and pregnancy remains a prevalent issue among women of reproductive age.
Denise Furness, Nguyen Khanh Trang Huynh, Ligaya Kaufmann, Jue Liu, Thi Bich Ngoc Nguyen, Ella Schaefer, Lucy Tan, Ching Danica Yau, Qi Yu   +8 more
doaj   +1 more source

Compliance of Healthcare Workers with Hand Hygiene Practices in the Northeast of Iran: an Overt Observation [PDF]

, 2018
Hand hygiene (HH) is one of the most effective methods to prevent transmission and spread of microorganisms from one patient to another, also, it used to reduce the spread of pathogens in clinical settings and to help control outbreaks but compliance is ...
Ghazvini, K. (Kiarash), Nezhad, R. V. (Reza), Yaghoubi, A. (Atieh)   +2 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Desafios na tipificação penal do sequestro digital (ransomware)

Boletim IBCCRIM
O artigo visa examinar as dificuldades da tipificação do ransomware no Direito Penal brasileiro, para cumprimento dos compromissos da Convenção de Budapeste contra o cibercrime, pela gravidade dos ataques cibernéticos contra empresas e a inadequação de ...
Claudia da Costa Bonard de Carvalho
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Diversity management in East Asian universities: focusing on the inclusion of international students/faculty and gender equality in Japanese universities

Journal of Contemporary East Asia Studies
This paper discusses the current status and challenges of diversity and inclusion in East Asian universities, particularly in Japan. Diversity has primarily been examined in the field of business administration and has been actively debated in the United
Kunimitsu Mamiya
doaj   +1 more source

Theory of Regulatory Compliance for Requirements Engineering [PDF]

, 2010
Regulatory compliance is increasingly being addressed in the practice of requirements engineering as a main stream concern. This paper points out a gap in the theoretical foundations of regulatory compliance, and presents a theory that states (i) what it
Jureta, Ivan, Mylopoulos, John, Perini, Anna, Siena, Alberto, Susi, Angelo   +4 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

GC–MS method for routine analysis of camphor, menthol, methyl salicylate, and thymol in traditional topical products: Addressing compliance and adulteration from Malaysia's National Pharmaceutical Regulatory Agency

Results in Chemistry
Topical formulations like liniments, ointments, creams, and patches, commonly used for their therapeutic benefits, often rely on potent active compounds such as camphor, menthol, methyl salicylate, and thymol.
Muhammad Amirul Amil, Kok Zheng Gan, Muhammad Shahariz Mohamad Adzib, Nur Baizura Bujang, Ahmad Yusri Mohd Yusop, Mohd Rohaizad Md Roduan   +5 more
doaj   +1 more source